Articles Vol. 67 No. CĐ4-HN Ký sinh trùng-HN Hóa sinh 2026 14/04/2026

ASSOCIATIED T-CD4 CELL COUNT AND OROPHARYNGEAL CANDIDOSIS IN PATIENTS WITH HIV/AIDS

Tran Thi Hue Van1,2
1 Department of Microbiology and Parasitology, Faculty of Medicine - Department of Laboratory Testing, Faculty of Nursing and Medical Technology, University of Medicine and Pharmacy at Ho Chi Minh City
2 Bộ môn Vi sinh Ký sinh Khoa Y - Bộ môn xét nghiệm Khoa điều dưỡng kỹ thuật y học, Trường Đại học Y Dược Thành phố Hồ Chí Minh
DOI: 10.52163/yhc.v67iCD4.4682
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Keywords
Oropharyngeal candidosis, Candida albicans, HIV/AIDS, T-CD4.
Abstract

Oropharyngeal candidiasis (OPC) remains the most common and recurrent opportunistic infection among people living with HIV/AIDS.
Objective: This study aimed to evaluate the association between CD4+ T-cell counts and the prevalence of OPC in HIV-infected patients.
Methods: A cross-sectional study was conducted among 52 HIV-positive outpatients at Thuan An City Medical Center, Binh Duong Province, from December 2023 to June 2024. Oral swab specimens were collected for fungal isolation and species identification. Absolute CD4+ T-lymphocyte counts were determined using flow cytometry.
Results: The overall prevalence of Candida spp. was 57.7%, with Candida albicans being the predominant species (50%). Patients were stratified according to CD4+ T-cell counts into two groups: ≥300 cells/mm³ (53.8%) and <300 cells/mm³ (46.2%). Most participants (36.5%) had received antiretroviral therapy (ART) for 31–90 days. No statistically significant association was observed between overall Candida spp. infection and ART duration (p = 0.819) or CD4+ T-cell levels (p = 0.080). However, a significant association was found between C. albicans infection and patients whose CD4+ T-cell counts <300 cells/mm³ (p = 0.029).
Conclusion: The risk of C. albicans infection in HIV/AIDS patients with CD4+ T-cell counts <300 cells/mm³ was 3.6 times higher than in those with CD4+ T-cell counts ≥300 cells/mm³

 

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