Articles Vol. 63 No. 6 (2022) 09/11/2022

THYMIC SQUAMOUS CELL CARCINOMA - CASE REPORT AND DOCUMENTARY OVERVIEW

Cung Van Cong1,2
1 National Lung Hospital
2 Bệnh viện Phổi trung ương
Corresponding author: vancong13071964@gmail.com
DOI: 10.52163/yhc.v63i6.462
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Keywords
Thymic Carcinoma, Thymic Squamous Cell Carcinoma, Immunohistochemistry.
Abstract

Histopathological classification of thymic tumors 2015, WHO update 2021, thymic carcinomas are
divided into 3 large groups: Thymoma/benign thymic tumors; Thymic carcinoma/ Thymus cancer;
Thymic neuroendocrine/ Neuroendocrine thymoma.
Thymic carcinoma (Thymic Carcinoma - TC) accounts for 70% of cases of Thymoma; In which, the
type of squamous carcinoma (Thymic Squamous Cell Carcinoma -TSCC) is very rare, diagnosed
based on histopathology criteria and immunohistochemistry. Patients with TSCC also often have
clinical symptoms associated with mediastinal tumor: Invasion of intramediastinal structures is
common, including superior vena cava syndrome; However, the common paraneoplastic syndromes
in thymoma such as myasthenia gravis, erythrocytosis, and hypogammaglobulinemia are very rare
in TSCC. TSCC has a very high malignancy and is often metastasized. The detection rate of distant
metastases is up to 50-65% at the time of diagnosis. Common sites of metastasis include lung, liver,
brain, and bone. The prognosis for TSCC is very poor with a 5-year survival rate of 30%. The mean
age at diagnosis was 50.
We introduce a 70-year-old male patient, who came to the National Lung Hospital for examination
and treatment, was diagnosed with TSCC by histopathology and immunohistochemistry with a
diagnostic approach to help colleagues industry for reference.

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