Articles Vol. 67 No. 3 31/03/2026

FACTORS ASSOCIATED WITH QUALITY OF LIFE IN ELDERLY PATIENTS WITH KNEE OSTEOARTHRITIS

Cao Thanh Ngoc1,2,3,4, Nguyen Thi Ai Tram2,4, Pham Huynh Tuong Vy2,4
1 Ho Chi Minh City University of Medicine and Pharmacy
2 University Medical Center of Ho Chi Minh City
3 Đại học Y Dược TP. Hồ Chí Minh
4 Bệnh viện Đại học Y Dược TP. Hồ Chí Minh
DOI: 10.52163/yhc.v67i3.4602
19 Views
14 Downloads
Keywords
knee osteoarthritis, elderly, SF-36, PCS, MCS, VAS, WOMAC.
Abstract

Objective: To investigate the associations of SF-36, including the Physical Component Summary (PCS) and Mental Component Summary (MCS), with sociodemographic factors, pain severity by VAS, and WOMAC domains in elderly patients with knee osteoarthritis (KOA).

Subjects and Methods: A cross-sectional study was conducted in 333 patients aged ≥60 years with KOA diagnosed according to the 1991 ACR criteria at the University Medical Center Ho Chi Minh City from December 2023 to May 2024. Quality of life was assessed using SF-36, pain severity using VAS, and functional limitation using WOMAC. Data were analyzed using t-tests, ANOVA, Pearson correlation, and multivariable linear regression.

Results: SF-36 score decreased with increasing pain severity (p < 0.001); the mild pain group had the highest score (49.46 ± 14.31), and the severe pain group the lowest (28.94 ± 12.38). WOMAC 1 and WOMAC 3 were inversely correlated with PCS, MCS, and total SF-36 score, with WOMAC 3 showing the strongest correlation with total SF-36 score (r = −0.359; p < 0.001). In multivariable analysis, VAS and WOMAC 3 were associated with total SF-36 score, while age, sex, and education level were associated with some SF-36 components.

Conclusion: PCS, MCS and total SF-36 score were associated with age, sex, education level, pain severity and functional limitation in elderly patients with KOA.

References
[1]
Võ Tuấn Khoa. Nghiên cứu về bản đánh giá chất lượng cuộc sống Short-Form (SF)-36 và ứng dụng để đánh giá chất lượng cuộc sống cho bệnh nhân đái tháo đường sau đoạn chi tại Bệnh viện Chợ Rẫy. Luận văn Thạc sĩ Y học. Đại học Y Dược TP Hồ Chí Minh; 2007. Google Scholar
[2]
Alkan BM, Fidan F, Tosun A, Ardıçoğlu O. Quality of life and self-reported disability in patients with knee osteoarthritis. Mod Rheumatol. 2014;24(1):166–171. doi:10.3109/14397595.2013.854046. Google Scholar
[3]
Allen KD, Thoma LM, Golightly YM. Epidemiology of osteoarthritis. Osteoarthritis Cartilage. 2022;30(2):184–195. doi:10.1016/j.joca.2021.04.020. Google Scholar
[4]
Derraik JG, de Bock M, Hofman PL, Cutfield WS. Increasing BMI is associated with a progressive reduction in physical quality of life among overweight middle-aged men. Sci Rep. 2014;4:3677. doi:10.1038/srep03677. Google Scholar
[5]
Figueiredo Neto EM, Queluz TT, Freire BF. Physical activity and its association with quality of life in patients with osteoarthritis. Rev Bras Reumatol. 2011;51(6):544–549. Google Scholar
[6]
Gomes-Neto M, Araujo AD, Junqueira ID, Oliveira D, Brasileiro A, Arcanjo FL. Comparative study of functional capacity and quality of life among obese and non-obese elderly people with knee osteoarthritis. Rev Bras Reumatol Engl Ed. 2016;56(2):126–130. doi:10.1016/j.rbre.2015.08.014. Google Scholar
[7]
Jhun HJ, Sung NJ, Kim SY. Knee pain and its severity in elderly Koreans: prevalence, risk factors and impact on quality of life. J Korean Med Sci. 2013;28(12):1807–1813. doi:10.3346/jkms.2013.28.12.1807. Google Scholar
[8]
Kawano MM, Araújo IL, Castro MC, Matos MA. Assessment of quality of life in patients with knee osteoarthritis. Acta Ortop Bras. 2015;23(6):307–310. doi:10.1590/1413-785220152306150596. Google Scholar
[9]
Kee CC. Older adults with osteoarthritis: psychological status and physical function. J Gerontol Nurs. 2003;29(12):26–34. doi:10.3928/0098-9134-20031201-07. Google Scholar
[10]
Pang J, Cao YL, Zheng YX, Gao NY, Wang XZ, Chen B, et al. Influence of pain severity on health-related quality of life in Chinese knee osteoarthritis patients. Int J Clin Exp Med. 2015;8(3):4472–4479. Google Scholar
[11]
Pinto Barbosa S, Marques L, Sugawara A, Toledo F, Imamura M, Battistella L, et al. Predictors of the health-related quality of life (HRQOL) in SF-36 in knee osteoarthritis patients: a multimodal model with moderators and mediators. Cureus. 2022;14(7):e27339. doi:10.7759/cureus.27339. Google Scholar
[12]
Salaffi F, Carotti M, Stancati A, Grassi W. Health-related quality of life in older adults with symptomatic hip and knee osteoarthritis: a comparison with matched healthy controls. Aging Clin Exp Res. 2005;17(4):255–263. doi:10.1007/BF03324607. Google Scholar
[13]
Thumboo J, Chew LH, Lewin-Koh SC. Socioeconomic and psychosocial factors influence pain or physical function in Asian patients with knee or hip osteoarthritis. Ann Rheum Dis. 2002;61(11):1017–1020. doi:10.1136/ard.61.11.1017. Google Scholar
[14]
Yuniarwati W, Subijanto AA, Prasetyo H. Determinants of quality of life among patients with knee osteoarthritis. J Epidemiol Public Health. 2019;4(4):320–327. doi:10.26911/jepublichealth.2019.04.04.07. Google Scholar
[15]
Zakaria ZF, Bakar AA, Hasmoni HM, Rani FA, Kadir SA. Health-related quality of life in patients with knee osteoarthritis attending two primary care clinics in Malaysia: a cross-sectional study. Asia Pac Fam Med. 2009;8(1):10. doi:10.1186/1447-056X-8-10. Google Scholar