Articles Vol. 67 No. 2 02/03/2026

EVALUATION OF INFECTION STATUS OF SKULL BONE TISSUES PRESERVED AT THE TISSUE BANK OF VIET DUC UNIVERSITY HOSPITAL

Nguyen Van Chinh1,2, Tran Thi Hang1,2, Do Thanh Hoa1,2, Duong Cong Nguyen1,2, Nguyen Thi Diem1,2, Ha Van Phu1,2, Tran Thi Thanh Huyen1,2, Nguyen Thu Hanh1,2, Hoang Minh Anh3,4
1 Viet Duc University Hospital
2 Bệnh viện Hữu nghị Việt Đức
3 University of Medicine and Pharmacy, Vietnam National University, Hanoi
4 Trường Đại học Y Dược, Đại học Quốc gia Hà Nội
DOI: 10.52163/yhc.v67i2.4345
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Keywords
Skull bone tissues, contamination, tissue banking, microorganisms.
Abstract

Objective: Describe the infection situation and characteristics of bacteria isolated on preserved skull bone tissue.

Subjects and methods: Descriptive, retrospective study of 1162 skull bone tissue samples randomly selected from tissues preserved at the tissue bank of Viet Duc University Hospital.

Results: 1162 patients including 898 men (77.28%), 264 women (22.72%); 1067 cases (91.82%) had craniotomy due to traumatic brain injury. The infection rate before radiation was 4.56%; after radiation was 0.17%. Common bacterial strains were Staphylococcus aureus (15.52%), Staphylococcus epidermidis (15.52%) and Pseudomonas aeruginosa (13.79%). Bone fragments with multiple fascia, hematoma, and crushed fractures had an infection rate of 7.65%, higher than the group with clean bone fragments of 4.38%. The infection rate according to the transportation time within the day (≤ 24 hours) was 1.88%; from 1-2 days was 4.72%, from 3-7 days was 7.65%, and over 7 days was 6.52%. Samples from external hospitals had a contamination rate of 9.38%, significantly higher than that of internal hospital samples (0.48%) (p < 0.01).

Conclusion: The infection rate before irradiation was 4.56%, which decreased to 0.17% post-irradiation. S.aureus, S.epidermidis, and P.aeruginosa are common bacterial strains. The process of collecting, processing, and preserving skull bone tissue has many factors that contribute to the increased risk of infection.

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