Articles Tập 67 Số CĐ1-NCKH 27/01/2026

ACUTE TOXICITY ASSESSMENT OF GERC7 FROM NGHE BO CAP (CURCUMA RANGJUED) RHIZOME EXTRACT WITH POTENTIAL CARDIOPROTECTIVE EFFECTS

Phung Thi Kim Hue1,2,3,4, Mai Phuong Thanh5,6, Phan Anh Thu2,4, Nguyen Nhat Long2,4, Nguyen Thi Duong7,8, Le Dung Sy1,3, Le Nhat Minh9,10, Phan Nu Yen Chi11, Le Tri Vien1,3
1 Institute of Health Research and Educational Development in Central Highlands
2 Hung Vuong High School for the Gifted
3 Viện Nghiên cứu Sức khỏe và Phát triển Giáo dục Tây Nguyên
4 Trường Trung học phổ thông chuyên Hùng Vương
5 Department of Pharmacology, VNU University of Medicine and Pharmacy
6 Bộ môn dược lí, Trường Đại học Y Dược, Đại học Quốc gia Hà Nội
7 Thao Nguyen Duong Traditional Medicine Clinic
8 Phòng khám Đông y Thảo Nguyên Đường
9 Foreign Trade University
10 Trường Đại học Ngoại thương
11 Life Sciences, Soka University of America
DOI: 10.52163/yhc.v67iCD1.4266
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Keywords
Curcuma rangjued, acute toxicity, GERC7, mouse model, cardiovascular disease.
Abstract

Objective: To evaluate the acute toxicity assessment of Curcuma rangjued extracts (GERC7) in mice.

Methodology: Acute toxicity testing was conducted in accordance with the OECD guideline 420 and the Vietnamese Ministry of Health’s Guidelines for preclinical and clinical testings of traditional medicine and herbal drugs on October 27, 2015.

Results: At doses of 75 mL/kg/day, GERC7 did not cause acute toxicity in white mice via oral administration.

Conclusions: Curcuma rangjued is a promising medicinal resource, proven to be safe and non-toxic at doses up to 75 mL/kg/day in experimental mice, when the extract is produced by steam distillation to create the GERC7.

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