Articles Tập 67 Số CĐ1-NCKH 27/01/2026

CLINICAL AND LABORATORY PROFILES OF COMMON PEDIATRIC NEPHRO-UROLOGICAL DISORDERS MANAGED AT THE PEDIATRICS DEPARTMENT, DUC GIANG GENERAL HOSPITAL (2023–2025)

Nguyen Thi Phuong Thao1,2, Do Manh Hien3,4, Nguyen Viet Quy5,6, Nguyen Van Thuong7,8
1 Đuc Giang general Hospital, Ha Noi, Vietnam
2 Bệnh viện Đa khoa Đức Giang
3 Vinmec Times City International Hospital, Hanoi
4 Bệnh viện Đa khoa Quốc tế Vinmec Timescity
5 KUSUMI University Hospital, Hung Yen,Vietnam
6 Bệnh viện Kusumi
7 Thanh Nhan general Hospital, Ha Noi, Vietnam
8 Bệnh viện Đa khoa Thanh Nhàn
DOI: 10.52163/yhc.v67iCD1.4262
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Keywords
Nephrotic Syndrome, Urinary Tract Infection, Clinical Characteristics and Laboratory Characteristics.
Abstract

Objective: To describe Clinical and Laboratory Characteristics of Urinary Tract Infections and Nephrotic Syndrome in Children Aged Over 2 Months at Duc Giang General Hospital, 2023–2025

Methods: A retrospective and prospective descriptive study was conducted on 50 retrospective medical records collected from January 2023 to December 2024 and 24 prospectively enrolled patients recruited from January 2025 to June 2025.

Results: Among common renal and urinary tract diseases treated in the pediatric department, urinary tract infections accounted for 86.4%, while nephrotic syndrome accounted for 13.6%. The mean peripheral white blood cell count was 14.22 ± 4.88 G/L, with leukocytosis observed in 75% of cases. The mean percentage of neutrophils was 52.81 ± 16.6%, with elevated levels found in 12.5% of patients. The mean CRP concentration was 26.2 ± 24.3 mg/L, and elevated CRP was present in 73.4% of cases.

Among 64 patients with UTIs, urine culture was performed in 47 cases, yielding 11 positive cultures (17.1%) and 36 negative cultures (56.3%). Escherichia coli was the most isolated pathogen, accounting for 10.9% of cases. Abnormal ultrasonographic findings of renal pelvic dilation were observed in 7.8% of patients.

In children with nephrotic syndrome, 70% had a urinary protein-to-creatinine ratio >3000 mg. microscopic hematuria was detected in 40% of cases at level (+) and 10% at level (++). Laboratory findings showed a mean serum albumin level of 19.1 ± 1.6 g/L and a mean total protein level of 44.9 ± 4.6 g/L. Mean serum urea, creatinine, potassium, calcium, and cholesterol levels were 5.0 ± 1.1 mmol/L, 42.9 ± 7.2 µmol/L, 4.0 ± 0.5 mmol/L, 1.8 ± 0.4 mmol/L, and 11.3 ± 1.8 mmol/L, respectively. Ultrasonography revealed ascites in 70% of patients.

Conclusion: Children diagnosed with urinary tract infections or nephrotic syndrome at Duc Giang General Hospital exhibited the typical clinical and laboratory manifestations of these conditions. The study’s findings contribute to improving early diagnosis, timely treatment, and the implementation of preventive measures and complication monitoring in affected children at Duc Giang General Hospital.

References
[1]
Lê Thị Hồng Điệp (2002), Đặc điểm lâm sàng và đáp ứng với Corticoid trong giai đoạn điều trị đầu tiên của hội chứng thận hư tiên phát ở trẻ em dưới 2 tuổi, Luận văn thạc sỹ y học, trường Đại học Y Hà Nội, tr 57-68. Google Scholar
[2]
Lê Quang Phương, Phạm Văn Đếm, Nguyễn Thị Quỳnh Hương (2016), Thực trạng nhiễm khuẩn đường tiểu trên trẻ từ 2 tháng đến 5 tuổi có sốt tại khoa khám bệnh, Bệnh viện Nhi Trung ương, Tạp chí Khoa học ĐHQGHN: Khoa học Y Dược, tr 45-50. Google Scholar
[3]
Lymuny Sathya: (2007): Đặc điểm dịch tễ học, lâm sàng và cận lâmnsàng của HCTH tiên phát ở trẻ em, Luận văn thạc sỹ Y học, Đại học Y Hà Nội, tr 25-45. Google Scholar
[4]
Lê Nam Trà (2009), “Hội chứng thận hư”, Bài giảng nhi khoa tập II, NXB Y học, Tr.157-167 Google Scholar
[5]
Sitthisarunkul N., Uthairat M., Dissaneewate P., et al. (2019). Characteristics and Findings of Childhood Urinary Tract Infection in the Last Decade. Urol Int, 102(4), 456–461, Urol Int. 2019;102(4):456–461. doi: 10.1159/000497443. Google Scholar
[6]
SUBCOMMITTEE ON URINARY TRACT INFECTION (2016). Reaffirmation of AAP Clinical Practice Guideline: The Diagnosis and Management of the Initial Urinary Tract Infection in Febrile Infants and Young Children 2-24 Months of Age. PEDIATRICS, 138(6), Pediatrics. 2016;138(6): e20163026. doi: 10.1542/peds.2016-3026. Google Scholar
[7]
Kunin C.M. and DeGroot J.E. (1977). Sensitivity of a nitrite indicator strip method in detecting bacteriuria in preschool girls. Pediatrics, 60(2), 244 245. Google Scholar
[8]
Katherine T Mills, Yu Xu, Weidong Zhang (2015), Abstract MP40: Global Burden of Chronic Kidney Disease in 2010: A Pooling Analysis of Population-Based Data Worldwide, Originally Published 4 March 2015, Volume 131, Number suppl_1. Google Scholar
[9]
Shaikh et a, 2020, Procalcitonin, C-reactive protein, and erythrocyte sedimentation rate for the diagnosis of acute pyelonephritis in children (update). Cochrane Database Syst Rev. 2020;9(9):CD009185. doi: 10.1002/14651858.CD009185.pub3. Google Scholar
[10]
Park HN, Kim SY, Lee NM, et al, 2022, Usefulness of Procalcitonin in the Diagnosis of Bacterial Infection in Immunocompetent Children. Children (Basel). 2022;9(8):1263. doi:10.3390/children9081263. Google Scholar