Articles Tập 67 Số CĐ1-NCKH 27/01/2026

COMMENTS ON THE RESULTS OF CHORIONIC VILLUS SAMPLING AT HANOI OBSTETRICS AND GYNECOLOGY HOSPITAL

Ho Khanh Dung1,2, Nguyen Duy Anh3,4, Mai Trong Hung5,6, Nguyen Thi Sim1,2, Ngo Thi Huong5,6
1 Phenikaa University Hospital
2 Bệnh viện Đại học Phenikaa
3 National Obstetrics and Gynecology Hospital
4 Bệnh viện Phụ sản Trung ương
5 Hanoi Obstetrics and Gynecology Hospital
6 Bệnh viện Phụ sản Hà Nội
DOI: 10.52163/yhc.v67iCD1.4222
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Keywords
Chorionic villus sampling, prenatal diagnosis, chromosomal abnormalities, single-gene disorders.
Abstract

Objective: To evaluate the results and diagnostic effectiveness of chorionic villus sampling at Hanoi Obstetrics and Gynecology Hospital.

Research methods: A descriptive retrospective study was conducted on 102 pregnant women who underwent chorionic villus sampling from January 2022 to June 2024.

Results: 100% success rate of sampling, no complications. Genetic abnormalities were detected in 49.02% of cases, including Down syndrome (18.63%), Edwards syndrome (4.90%), Patau syndrome (0.98%), sex chromosome abnormalities (3.92%), combined Edwards and sex chromosome abnormalities (0.98%), and single-gene disorders (19.61%). There was a significant correlation between high-risk NIPS and abnormal chorionic villus sampling results (p < 0.05). In 13 cases of abnormal ultrasound of organs with chromosomal abnormalities 11 cases (86.96%). Post-procedure pregnancy outcomes showed 49.02% termination due to severe genetic abnormalities, while 50.98% continued uneventfully.

Conclusions: Chorionic villus sampling is an early, accurate, and safe prenatal diagnostic method, particularly effective in pregnancies with high-risk NIPS or abnormal ultrasound findings.

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