Articles Vol. 67 No. 1 15/01/2026

CLINICAL, PARACLINICAL CHARACTERISTICS AND COLONOSCOPIC FINDINGS IN PATIENTS WITH ANKYLOSING SPONDYLITIS IN THAI NGUYEN

Le Thi Huong1,2, Doan Anh Thang3,4, Duong Hong Thai1,2,5,6, Le Anh Tuan7,8, Ha Thanh Tam5,6
1 University of Medicine and Pharmacy, Thai Nguyen University
2 Trường Đại học Y Dược, Đại học Thái Nguyên
3 University of Medicine and Pharmacy Hospital, Thai Nguyen University
4 Bệnh viện Trường Đại học Y Dược, Đại học Thái Nguyên
5 Thai Nguyen National Hospital
6 Bệnh viện Trung ương Thái Nguyên
7 Saint Paul General Hospital
8 Bệnh viện Đa khoa Xanh Pôn
DOI: 10.52163/yhc.v67i1.4099
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Keywords
Viêm khớp cột sống, tổn thương ruột, bệnh viêm ruột.
Abstract

Objective: Description of colonoscopic lesion characteristics and related factors in patients with spondyloarthritis treated in Thai Nguyen.

Subjects and methods: A cross-sectional descriptive study was conducted on 46 patients diagnosed with ankylosing spondylitis according to the 2009 ASAS criteria, from June 2024 to September 2025, at the Department of Rheumatology of Hospital A and Thai Nguyen National Hospital.

Results: The locations of joint pain observed clinically were most commonly in the axial joints, while peripheral joints were less frequently affected and typically involved the lower limbs. In the study group, 10.9% of patients presented with gastrointestinal symptoms, among which digestive disorders and abdominal pain were the most common. Colonoscopy results showed colonic mucosal lesions in 21.7% of cases. The most frequent sites of endoscopic lesions were the ileocecal region and the rectum. Congestion and edema were the two most common endoscopic lesion types. The degree of mucosal damage was generally mild, accounting for 10.9% of cases. There was a significant correlation between age at disease onset and the presence of peripheral arthritis symptoms with HLA-B27 positivity, as well as between gastrointestinal symptoms and endoscopic colonic lesions (p < 0.05).

Conclusion: Colonoscopy should be performed in patients with spondyloarthritis to detect early intestinal lesions, even in the absence of gastrointestinal symptoms, in order to facilitate early diagnosis and timely treatment.

References
[1]
Rudwaleit M, Baeten D. Ankylosing spondylitis Google Scholar
[2]
and bowel disease. Best Practice & Research Clinical Rheumatology, 2006, 20 (3): 451-71. https:// Google Scholar
[3]
doi.org/1. 1016/j.berh.2006.03.010 Google Scholar
[4]
Einat Savin, Niv Ben-Shabat et al. Biologic treatment modification efficacy in concurrent inflammatory bowel disease and ankylosing spondylitis: Google Scholar
[5]
a retrospective cohort study at a single tertiary Google Scholar
[6]
L.T. Huong et al. / Vietnam Journal of Community Medicine, Vol. 67, No. 1, 1-66 www.tapchiyhcd.vn center. Journal of Clinical Medicine, 2023, 12 (22): 7151. https://doi.org/10.3390/jcm12227151. Google Scholar
[7]
Nguyễn Thanh Kim Huệ, Nguyễn Thị Phương Thủy. Đặc điểm lâm sàng và cận lâm sàng của bệnh viêm khớp cột sống ở bệnh nhân nữ giới. Tạp chí Y học Việt Nam, 2022, 520 (1A): 1-5. https://doi.org/10.51298/vmj.v520i1.3724. Google Scholar
[8]
Hmy de Jong, Paramarta J.E et al. Differences between females and males in axial spondyloarthritis: data from a real-life cross-sectional cohort.Scandinavian Journal of Rheumatology, 2020, 49(1): 28-32. https://doi.org/10.1080/03009742.2019.1627410. Google Scholar
[9]
Ahn S.M, Kim Y.G et al. Ileocolonoscopic findings in patients with ankylosing spondylitis: a single center retrospective study. The Korean journal of internal medicine, 2017, 32 (5): 916. Soo Min Ahn 1, Yong-Gil Kim 1, Seung-Hyeon Bae. https://doi.org/10.3904/kjim.2015.313. Google Scholar
[10]
Chowdhury M.M.H et al. Colonoscopic findings and histological changes in patients suffering from ankylosing spondylitis with normal bowel habit. TAJ: Journal of Teachers Association, 2009, 22 (1): 1-4. https://doi.org/10.3329/taj.v22i1.5012. Google Scholar
[11]
Bulut G.D, Rıdvan M, Berrak K, Hilmi T. Low frequency of HLA-B27 in ankylosing spondylitis patients from Turkey: Insights from the Thrace region. Medical Science Monitor: International Medical Journal of Experimental Clinical Research, 2025, 31: e948449. https://doi.org/10.12659/msm.948449 Google Scholar
[12]
Arévalo M, Masmitjà J.G et al. Influence of HLA-B27 Google Scholar
[13]
on the ankylosing spondylitis phenotype: results Google Scholar
[14]
from the REGISPONSER database. Arthritis Research & Therapy, 2018, 20 (1): 221. https://doi.org/10.1186/s13075-018-1724-7 Google Scholar