Objective: To evaluate the degree of cirrhosis of the pediatric patients treated with Kasai surgery at
the National Children’s Hospital through the APRi index.
Subjects and Methods: A retrospective descriptive study of a 172 patients diagnosed with congenital
biliary atresia, treated by Kasai surgery with extensive hilar fibrosis at National Children’s Hospital
from January 2016 to December 2020.
Result: The mean APRi index before surgery was 1.77±1.43. Mean APRi score re-evaluated after
1 month was 1.9± 4.34 and the mean APRi after 6 months was 1.71±2.9. Comparison of APRi
scores before surgery and 6 months after surgery showed a statistically significant difference with p
< 0.0001.
Conclusion: The APRi index before surgery and 6 months after surgery is closely related to the
mortality rate after Kasai surgery to treat congenital biliary atresia in children.
EVALUATE OF LIVER CIRRHOSIS BY THE APRI INDEX IN KASAI SURGERY TO TREAT CONGENITAL BILIARY ATRESIA TYPE III
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Keywords
Kasai, APRi, biliary atresia.
Abstract
References
[1]
Department of Pediatric Surgery Ho Chi Minh
Google Scholar
[2]
City University of Medicine and Pharmacy.
Google Scholar
[3]
Clinical Pediatric Surgery. Medical Publishing
Google Scholar
[4]
House; 2018.
Google Scholar
[5]
Nio M, Ohi R, Historical Overview of Biliary
Google Scholar
[6]
Atresia. In: Introduction to Biliary Atresia.
Google Scholar
[7]
Springer; 2021:1-6.
Google Scholar
[8]
Kasai M, Kimura S, Asakura Y et al., Surgical
Google Scholar
[9]
treatment of biliary atresia. Journal of pediatric
Google Scholar
[10]
surgery. 1968; 3(6):665-675.
Google Scholar
[11]
Liem NT, Diagnosis of congenital biliary atresia.
Google Scholar
[12]
Practical Medicine. 1997; 3:58-60.
Google Scholar
[13]
Grieve A, Makin E, Davenport M, Aspartate
Google Scholar
[14]
aminotransferase-to-platelet ratio index (APRi)
Google Scholar
[15]
in infants with biliary atresia: prognostic value at
Google Scholar
[16]
presentation. Journal of pediatric surgery. 2013;
Google Scholar
[17]
(4):789-795.
Google Scholar
[18]
De Maayer T, Lala S, Loveland J et al., Outcomes
Google Scholar
[19]
of Kasai hepatoportoenterostomy in children
Google Scholar
[20]
with biliary atresia in Johannesburg, South
Google Scholar
[21]
Africa. South African Medical Journal. 2017;
Google Scholar
[22]
(10):S7-S11.
Google Scholar
[23]
Gad EH, Kamel Y, Salem TA-H et al., Short-and
Google Scholar
[24]
long-term outcomes after Kasai operation for type
Google Scholar
[25]
III biliary atresia: Twenty years of experience in
Google Scholar
[26]
a single tertiary Egyptian center-A retrospective
Google Scholar
[27]
cohort study. Annals of Medicine and Surgery.
Google Scholar
[28]
; 62:302-314.
Google Scholar
[29]
Suominen JS, Lampela H, Heikkilä P et al., APRi
Google Scholar
[30]
predicts native liver survival by reflecting portal
Google Scholar
[31]
fibrogenesis and hepatic neovascularization at
Google Scholar
[32]
the time of portoenterostomy in biliary atresia.
Google Scholar
[33]
Journal of pediatric surgery. 2015; 50(9):1528-
Google Scholar
[34]
Wang LY, Yuan CY, Zhan J, Early differential
Google Scholar
[35]
diagnosis methods of biliary atresia: a metaanalysis. Pediatric surgery international. 2018;
Google Scholar
[36]
(4):363-380.
Google Scholar