Objective: To evaluate the rate of target achievement of LDL-C in high and very high cardiovascular
risk patients. Methods: A retrospective study of cardiology outpatient database in Nhan dan Gia
Dinh Hospital from 2020 January to 2021 January was conducted. Prescriptions before and after lipid
investigation were collected to consider the statin prescription behavior. Results: LDL-C targets
were achieved in 29.17% and 8.24% of high risk and very high risk patients, respectively. A majority
(83.46%) were on intermediate intensity and 16.54% were on high intensity statin treatment. Statin
dose increment rate was 23.21% in unachieved LDL-C patients. Conclusion: LDL-C achievement
rates were modest in high and very high cardiovascular risk patients while the statin prescription was
not adequate.
LDL CHOLESTEROL ACHIEVEMENT IN HIGH AND VERY HIGH CARDIOVASCULAR RISK PATIENTS ACCORDING TO EUROPEAN SOCIETY OF CARDIOLOGY 2019 GUIDELINE
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Keywords
Dyslipidemia, LDL-C, high and very high cardiovascular risk, statin.
Abstract
References
[1]
Mach F, “2019 ESC/EAS Guidelines for
Google Scholar
[2]
the management of dyslipidaemias: lipid
Google Scholar
[3]
modification to reduce cardiovascular riskThe
Google Scholar
[4]
Task Force for the management of dyslipidaemias
Google Scholar
[5]
of the European Society of Cardiology (ESC) and
Google Scholar
[6]
European Atherosclerosis Society (EAS),” Eur.
Google Scholar
[7]
Heart J., vol. 41, no. 1, pp. 111–188, Jan. 2020.
Google Scholar
[8]
Bruckert E, “Proportion of High-Risk/Very
Google Scholar
[9]
High-Risk Patients in Europe with LowDensity Lipoprotein Cholesterol at Target
Google Scholar
[10]
According to European Guidelines: A
Google Scholar
[11]
Systematic Review,” Adv. Ther., vol. 37, no.
Google Scholar
[12]
, pp. 1724–1736, May 2020.
Google Scholar
[13]
Petrov I, “Clinical Management of High and
Google Scholar
[14]
Very High Risk Patients with Hyperlipidaemia
Google Scholar
[15]
in Central and Eastern Europe: An Observational
Google Scholar
[16]
Study,” Adv. Ther., vol. 36, no. 3, p. 608, Mar.
Google Scholar
[17]
, doi: 10.1007/S12325-019-0879-1.
Google Scholar
[18]
Krittayaphong R, “The rate of patients at high
Google Scholar
[19]
risk for cardiovascular disease with an optimal
Google Scholar
[20]
low-density cholesterol level: a multicenter study
Google Scholar
[21]
from Thailand,” J. Geriatr. Cardiol., vol. 16, no.
Google Scholar
[22]
, p. 344, 2019.
Google Scholar
[23]
Vrablik M, “Lipid-lowering therapy use in
Google Scholar
[24]
primary and secondary care in Central and
Google Scholar
[25]
Eastern Europe: DA VINCI observational study,”
Google Scholar
[26]
Atherosclerosis, vol. 334, pp. 66–75, Oct. 2021.
Google Scholar
[27]
Naito R, Miyauchi K, Daida H, “Racial
Google Scholar
[28]
Differences in the Cholesterol-Lowering Effect
Google Scholar
[29]
of Statin,” J. Atheroscler. Thromb., vol. 24, no.
Google Scholar
[30]
, p. 19, 2017.
Google Scholar
[31]
Newman CB, “Statin Safety and Associated
Google Scholar
[32]
Adverse Events: A Scientific Statement From
Google Scholar
[33]
the American Heart Association,” Arterioscler.
Google Scholar
[34]
Thromb. Vasc. Biol., vol. 39, no. 2, pp. E38–E81,
Google Scholar
[35]
Feb. 2019.
Google Scholar
[36]
Goldberg KC, “Overcoming inertia: improvement
Google Scholar
[37]
in achieving target low-density lipoprotein
Google Scholar
[38]
cholesterol,” Am J Manag Care., vol. 13, no. 9,
Google Scholar
[39]
p. 540-4, 2007.
Google Scholar