Articles Vol. 63 No. 4 (2022) 08/08/2022

ASSESSMENT OF KI-67 EXPRESSION IN HISTOPATHOLOGICAL SUBTYPES NON-HODGKIN'S B-CELL LYMPHOMA

Nguyen Khac Tuyen1,2, Dau Van Nhu1,2, Nguyen Cong Truong1,2, Tran Viet Hieu1,2, Nguyen Tien Dung1,2, Hoang Thi Lam1,2, Le Thi Linh3,4, Tran Ngoc Dung5,6
1 Military Hospital 175
2 Bệnh viện Quân y 175
3 Oncology Hospital - Ho Chi Minh City
4 Bệnh viện Ung Bướu thành phố Hồ Chí Minh
5 Military Hospital 103
6 Bệnh viện Quân y 103
Corresponding author: khactuyenqy@gmail.com
DOI: 10.52163/yhc.v63i4.365
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Keywords
Non-Hodgkin’s lymphoma (NHL), Ki67 marker.
Abstract

Objective: Histopathology classification of non-Hodgkin’s lymphoma (NHL) B-cell lineage and
evaluation of the immunohistochemical expression of Ki67 marker in histopathological subtypes
Non-Hodgkin’s B-cell lymphoma.
Matherial and Methods: A cross-sectional study of formalin-fixed paraffin-embedded samples
of 69 patients were confirmed as non-Hodgkin lymphoma B-cell (NHL) by histopathological and
immunohistochemistry techniques from January 2018 to January 2021, at Military Hospital 103.
Comment on histopathological characteristics, immunohistochemical expression marker and the
collected data analysis.
Result: Diffuse large B-cell lymphoma is the most common histopathologic subtype (76.80%), with
the average expressional value of Ki67 is 62.9 ± 14.7, the lowest value is 20, the highest is 90. The
Ki67 index of the FL, SLL/CLL, and MCL subtypes ranges from 20-30%, while the MZL has a Ki67
value ranging from 5-80%.
Conclusion: The Ki67 marker was expressed at a high rate in diffuse large B-cell lymphoma,
especially at a high level (≥65%) in most of the non-germinal center group.

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