Articles Vol. 66 No. CĐ16-HNKH Bệnh viện Nhi Đồng 2 02/10/2025

20. RESULTS OF HELICOBACTER PYLORI TREATMENT ACCORDING TO ANTIBIOTIC SUSCEPTIBILITY IN CHILDREN WITH GASTRITIS AND PEPTIC ULCERS AT CHILDREN'S HOSPITAL 2

Ho Quoc Phap1, Vo Hoang Khoa1, Nguyen Thi Kim Ngan1, Nguyen Vu Que Chi1, Nguyen Thi Thu Thuy1
1 Bệnh viện Nhi Đồng 2
Corresponding author: drquocphap@gmail.com
DOI: 10.52163/yhc.v66iCD16.3332
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Abstract

Objective: The aim of this study was to determine the antibiotic resistance rates of H. pylori and the eradication outcomes of first-line treatment regimens based on susceptibility testing in children at Children’s Hospital 2 from January to December 2024.

Methods: A retrospective descriptive case series study.

Results: From January to December 2024, 136 patients were included. The mean age was 9,6 ± 2,4 years, with the 6–10 years age group being the largest (46,3%). Females accounted for 53%. Family history of H. pylori infection was reported in 57.4%, indicating familial transmission risk. Nutritional status showed 53% normal, 29.4% underweight and 17,6% overweight, obese. Abdominal pain was the predominant symptom (93.4%). Upper gastrointestinal endoscopy revealed inflammatory lesions in 81% of cases and ulcerative lesions in 26,5%. Resistance rates were high for clarithromycin (100%), amoxicillin (77.9%) and metronidazole (69.8%), while resistance to levofloxacin and tetracycline was lower (31,6% and 2,2%, respectively). The overall eradication rate was 63.9%, about 77,9% of patients showed symptom improvement after treatment. There was a significant association between symptom improvement and successful eradication (OR = 5.31; p < 0,001).

Conclusion: This study showed a relatively high resistance rate of H. pylori to clarithromycin and amoxicillin. Therefore, choosing antibiotics based on susceptibility testing and personalizing treatment is important to improve eradication rates.

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