Articles Vol. 66 No. Vol 67. English Version No 2 11/06/2026

ASSOCIATION BETWEEN LEAD CONCENTRATIONS IN BLOOD, THYROID TISSUE, AND THYROID CANCER

Lam Nguyen Nha Truc1, Nguyen Van Chuyen2, Nguyen Thi Thu Trang2, Le Tuan Anh2, Hoang Thi Truong2, Vu Minh Tuan2, Doan Bao Ha2, Nguyen Thi Thao3, Ta Quang Thanh4, Tran Quang Phuc5, Nguyen Van Ba6
1 Cho Ray Hospital
2 Vietnam Military Medical University, Hanoi, Vietnam.
3 Ha Dong Hospital
4 Bac Thang Long hospital
5 The National Institute of Malariology, Parasitology and Entomology
6 Military hospital 175
DOI: 10.52163/yhc.v66i8.3233
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Keywords
Blood lead concentration, thyroid tissue lead concentration, thyroid cancer.
Abstract

Background: Current research on lead (Pb) in relation to the thyroid and particularly thyroid cancer remains limited.

Objective: To compare Pb concentrations in blood and thyroid tissue samples between the patient and control groups; evaluate the association between Pb concentrations and thyroid cancer.

Methods: A cross-sectional descriptive study was conducted on 282 patients with benign and malignant thyroid tumors at stages 1, 2, and 4. Lead concentrations in blood and thyroid tissue were measured, and their correlation with thyroid cancer was analyzed.

Results: The blood Pb concentration in the patient group was 1.27 ± 2.33 µg/L, while in the control group, it was 0.65 ± 2.35 µg/L. The Pb concentration in thyroid tissue for the benign and malignant groups was 15.26 ± 72.87 µg/kg and 36.88 ± 74.32 µg/kg, respectively. Logistic regression analysis showed that blood Pb levels in the malignant thyroid tumor group were higher than in the benign group (OR = 1.270; 95% CI: 1.011–1.594; p = 0.040). High Pb concentrations in thyroid tissue were associated with thyroid cancer (OR = 1.006; 95% CI: 1.000–1.011; p = 0.043).

Conclusion: High Pb concentrations in thyroid tissue and blood samples are associated with thyroid cancer.

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