Articles Vol. 66 No. CĐ13- HNKH Gây mê Hồi sức 25/09/2025

21. RELATIONSHIP BETWEEN DEPTH OF ANESTHESIA AND DOSAGE OF PROPOFOL DURING CARDIOPULMONARY BYPASS IN PATIENTS UNDERGOING OPEN HEART SURGERY

Hoang Thi Hoai Thu1,2, Nguyen Quoc Kinh3,4, Nguyen Thi Thuy Ngan3,4
1 Hanoi Medical Hospital
2 Trường Đại học Y Hà Nội
3 Viet Duc Friendship Hospital
4 Bệnh viện Hữu Nghị Việt Đức
Corresponding author: hoaithupbc98@gmail.com
DOI: 10.52163/yhc.v66iCD13.3187
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Keywords
BIS, Propofol, cardiopulmonary bypass, open-heart surgery.
Abstract

ABSTRACT

Objective: To evaluate the relationship between depth of anesthesia (BIS) and Propofol dose during the cardiopulmonary bypass (CPB) phase in patients undergoing open-heart surgery, to determine the role of BIS in individualizing anesthetic dosing.

Objects and methods: Observational and descriptive study and analysis on patients with indications for cardiovascular surgery using extracorporeal circulation at the Center for Anesthesia and Surgical Resuscitation, Viet Duc University Hospital from November 2024 to July 2025.

Results: Within a sample of 51 patients, the average BIS value during CPB was 44.14 ± 1.89, and the mean Propofol dosage was 2.91 ± 0.14 mg/kg/hour. BIS values showed a moderate negative correlation with Propofol dosage (r = -0.40; p = 0.003); and each increase of 1 mg/kg/hour in Propofol dosage led to an average 5.26 points decrease of 5.26 BIS.

Conclusion: BIS values are moderately and inversely correlated with Propofol dosage during cardiopulmonary bypass.

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