Articles Vol. 66 No. CĐ14-HNKH BV Giao thông Vận tải 12/01/2026

44. ASSESSMENT OF MEDICATION ADHERENCE USING THE MORISKY-8 SCALE (MMAS-8) IN OLDER PATIENTS WITH HEART FAILURE WITH REDUCED EJECTION FRACTION

Nguyen Thanh Huan1,2,3,4, Nguyen Thi Mai Huong2,4
1 Department of Geriatrics, University of Medicine and Pharmacy, Ho Chi Minh City.
2 Department of Cardiology, Thong Nhat Hospital
3 Bộ môn Lão khoa, Đại Học Y Dược Thành Phố Hồ Chí Minh.
4 Khoa Nội Tim mạch, Bệnh viện Thống Nhất
Corresponding author: huannguyen@ump.edu.vn
DOI: 10.52163/yhc.v66iCD14.3151
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Keywords
medication adherence, Morisky-8, older patients, heart failure with reduced ejection fraction
Abstract

Objectives: To assess the level of medication adherence and associated factors in older outpatients with HFrEF.

Methods: From July 2024 to May 2025, this cross-sectional study screened and recruited outpatients aged ≥60 years undergoing treatment for HFrEF at Thong Nhat Hospital and University Medical Center Ho Chi Minh City. Medication adherence was evaluated using the 8-item Morisky Medication Adherence Scale (MMAS-8). Logistic regression was employed to identify factors associated with low to medium levels of adherence.

Results: Among 293 analyzed patients (male: 60.1%, mean age: 72.9±9.3), the rates of high, medium, and low medication adherence were 25.9% (n = 76), 62.5% (n = 183), and 11.6% (n = 34), respectively. Forgetting to take medication was the most commonly reported issue (42.3%) based on MMAS-8 items. Multivariate logistic regression identified depression as a factor significantly associated with an increased likelihood of low to medium adherence (Odds Ratio 1.84; 95% Confidence Interval 1.06–3.22; P = 0.031).

Conclusions: In older patients with HFrEF, only about one-fourth demonstrated high medication adherence, with forgetfulness being the most prevalent cause. Depression, a common geriatric issue, was associated with poorer adherence in this patient population.

References
[1]
J. Bauersachs and S. Soltani. [Guidelines of the ESC 2021 on heart failure]. Herz, 2022, 47(1): 12-18. Google Scholar
[2]
Junjie Huang, Harry HX Wang, Zhijie Zheng và cộng sự. Medication adherence among the older adults: challenges and recommendations. 2020, 26(6): 476-478. Google Scholar
[3]
U. Religioni, R. Barrios-Rodríguez, P. Requena và cộng sự. Enhancing Therapy Adherence: Impact on Clinical Outcomes, Healthcare Costs, and Patient Quality of Life. Medicina (Kaunas), 2025, 61(1): Google Scholar
[4]
J. Culig and M. Leppée. From Morisky to Hill-bone; self-reports scales for measuring adherence to medication. Coll Antropol, 2014, 38(1): 55-62. Google Scholar
[5]
Philip A Poole-Wilson, Karl Swedberg, John GF Cleland và cộng sự. Comparison of carvedilol and metoprolol on clinical outcomes in patients with chronic heart failure in the Carvedilol Or Metoprolol European Trial (COMET): randomised controlled trial. 2003, 362(9377): 7-13. Google Scholar
[6]
S. Punnapurath, P. Vijayakumar, P. L. Platty và cộng sự. A study of medication compliance in geriatric patients with chronic illness. J Family Med Prim Care, 2021, 10(4): 1644-1648. Google Scholar
[7]
S. H. Ihm, K. I. Kim, K. J. Lee và cộng sự. Interventions for Adherence Improvement in the Primary Prevention of Cardiovascular Diseases: Expert Consensus Statement. Korean Circ J, 2022, 52(1): 1-33. Google Scholar
[8]
I. Liguori, G. Russo, F. Curcio và cộng sự. Depression and chronic heart failure in the elderly: an intriguing relationship. J Geriatr Cardiol, 2018, 15(6): 451-459. Google Scholar
[9]
K. Zivin and H. C. Kales. Adherence to depression treatment in older adults: a narrative review. Drugs Aging, 2008, 25(7): 559-71. Google Scholar