Articles Vol. 63 No. 2 (2022) 06/04/2022

Assessment on toxicity of fatty oil extracted from perilla seeds

Tran Ba Kien1,2, Duong Anh Tuyet3,4, Nguyen Thuy Duong3,4, Nguyen Thi Dong5,6
1 Hai Duong Central College of Pharmacy
2 Trường CĐ Dược Trung ương Hải Dương
3 Hanoi University of Pharmacy
4 Trường Đại học Dược Hà Nội
5 Administration of science technology and training
6 Cục Khoa học công nghệ và Đào tạo, Bộ Y tế
Corresponding author: Duonganhtuyetdkh@gmail.com
DOI: 10.52163/yhc.v63i2.315
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Keywords
Acute toxicity, semi-permanent toxicity, perilla seed oil.
Abstract

Fatty oil extracted from perilla seeds contains unsaturated fatty acids linolenic acid and linoleic acid which have good effects in lowering blood lipids. The study was conducted to determine the toxicity of perilla seed oil as a basis for developing production of perilla seed fatty oil into a safe product, supporting the treatment of dyslipidemia. The test results showed that the test product prepared from fatty oil extracted from perilla seeds at a dose of 40mL/kg (Acid linoleic 58,48%, acid linolenic 19,27%) – the highest dose that could be given to rats through a curved needle - did not show acute toxicity. When administered in repeated dose for 28 days, perilla seed oil showed no toxicity in rabbits.

References
[1]
Cardiovascular diseases, https://www.who.int/news-room/fact-sheets/detail/cardiovascular-diseases-(cvds), Accessed 20 June 2021 Google Scholar
[2]
To MT, Tram VT, Academic Pharmacology 2. Medical Publishing House, 2018. Google Scholar
[3]
Kyeong RL, Kyung HK, Jung BK, et al., High accumulation of γ-linolenic acid and Stearidonic acid in transgenic Perilla seeds. BMC Plant Biology, 2019; 19: 120. Google Scholar
[4]
Kim SR, Je J, Jeong K, et al., Perilla Oil Decreases Aortic and Hepatic Lipid Accumulation by Modulating Lipogenesis and Lipolysis in High-Fat Diet-Fed Mice, Journal of Medicinal Food 2018; 22(1), 14-21. Google Scholar
[5]
Guidelines for preclinical and clinical trials of traditional and herbal medicines - Ministry of Health, https://thuvienphapluat.vn/van-ban/The-thao-Y-te/Quyet-dinh-141-QD-K2DT-2015-Huong-dan-thu-nghiem-tien-lam-sang-lam-sang-thuoc-dong-y-414589.aspx. Accessed 14 March 2021. Google Scholar
[6]
OECD, Test Guidelines for Chemicals, OECD, 2021; Section 4, Test No. 407,420,423,425. Google Scholar
[7]
Shayne CG., Drug safetey evalution, Wiley, 2002. Google Scholar
[8]
Dam DT, How to express dosage of substances extracted from medicinal herbs. Medical Publishing House 2015; p. 565-568. Google Scholar
[9]
Zhang H, Guan J, Tian Y et al., Acute and sub-chronic 90-day oral toxicity study of Perilla seed oil in rodents and Beagle dogs, Regulatory Toxicology and Pharmacology, 2019; 103: 229-236. Google Scholar
[10]
Yang Z, Ren T, Lu D et al., Evaluating the safety of phytosterols removed perilla seed oil-based lipid emulsion, Taylor & Francis, 2016; 13(10): 1345-1356. Google Scholar