Articles Vol. 66 No. CĐ14-HNKH BV Giao thông Vận tải 12/01/2026

17. STEM CELL APPLICATION IN INFERTILITY TREATMENT

Pham Xuan Da1,2,3,4, Cao My Hang2,5, Ngo Duc Ngoc1,2,3,5
1 University of Medicine and Pharmacy -Vietnam National University
2 Transport Hospital
3 1) Trường Đại học Y Dược, Đại học Quốc gia Hà Nội
4 2) Bệnh viện Giao thông vận tải
5 2) Bệnh viện Giao thông vận tải.
Corresponding author: drdavn@gmail.com
DOI: 10.52163/yhc.v66iCD14.3070
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Abstract

Infertility is a reproductive health problem that affects the lives of many wives. The current world infertility rate is about 15%. Current assisted reproductive technologies can solve the problem in most cases. However, there are still a significant number of couples who are unable to conceive even after assisted reproduction is available. In such cases, stem cell therapy can offer hope to couples who wish to have children who are media similar to them. Extensive research is underway on induced pluripotent stem cells (iPSCs). Similarly, mesenchymal stem cells (MSCs) such as skeleton, adipose tissue, menstrual blood, endometriosis, slurry, and placenta, are gaining popularity for application in reproductive medicine. However, more large-scale clinical trials are needed for evidence of the safety and efficacy of stem cell-based therapies in the field of human reproduction.

References
[1]
TÀI LIỆU THAM KHẢO Google Scholar
[2]
Shapiro A, Kashani B, Seungdamrong A. Oral Ovulation Induction Agents. 2017, 37(13): 1-7. Google Scholar
[3]
Manshadi MD, Navid S, Hoshino Y, Daneshi E, Noory P, Abbasi M. The effects of human menstrual blood stem cells-derived granulosa cells on ovarian follicle formation in a rat model of premature ovarian failure. 2019, 82(6): 635-42. Google Scholar
[4]
Zheng SX, Wang J, Wang XL, Ali A, Wu LM, Liu YS. Feasibility analysis of treating severe intrauterine adhesions by transplanting menstrual blood-derived stem cells. Int J Mol Med, 2018, 41(4): 2201-12. Google Scholar
[5]
Yan Z, Guo F, Yuan Q, Shao Y, Zhang Y, Wang H, et al. Endometrial mesenchymal stem cells isolated from menstrual blood repaired epirubicin-induced damage to human ovarian granulosa cells by inhibiting the expression of Gadd45b in cell cycle pathway. Stem Cell Res Ther, 2019, 10(1): 4. Google Scholar
[6]
Zhao YA-O, Chen SA-O, Su PA-O, Huang FA-O, Shi YC, Shi QA-O, et al. Using Mesenchymal Stem Cells to Treat Female Infertility: An Update on Female Reproductive Diseases. Stem Cells Int, 2019: 9071720. Google Scholar
[7]
Xie QA-O, Xiong XA-O, Xiao N, He K, Chen M, Peng J, et al. Mesenchymal Stem Cells Alleviate DHEA-Induced Polycystic Ovary Syndrome (PCOS) by Inhibiting Inflammation in Mice. Stem Cells Int, 2019, (1687-966X (Print)): 9782373. Google Scholar
[8]
Xu L, Ding L, Wang L, Cao Y, Zhu H, Lu J, et al. Umbilical cord-derived mesenchymal stem cells on scaffolds facilitate collagen degradation via upregulation of MMP-9 in rat uterine scars. Stem Cell Res Ther, 2017, 18(1): 84. Google Scholar
[9]
Fan D, Wu S Fau - Ye S, Ye S Fau - Wang W, Wang W Fau - Guo X, Guo X Fau - Liu Z, Liu Z. Umbilical cord mesenchyme stem cell local intramuscular injection for treatment of uterine niche: Protocol for a prospective, randomized, double-blinded, placebo-controlled clinical trial. Medicine (Baltimore), 2017, 96(44): e8480. Google Scholar
[10]
Damous LL, Nakamuta JS, Carvalho AE, Carvalho KC, Soares JM, Jr., Simões Mde J, et al. Does adipose tissue-derived stem cell therapy improve graft quality in freshly grafted ovaries? Reprod Biol Endocrinol, 2015, 13: 108. Google Scholar
[11]
Saha SA-O, Roy P, Corbitt C, Kakar SS. Application of Stem Cell Therapy for Infertility. LID - 10.3390/cells10071613 [doi] LID - 1613. Cells, 2021, 10(7): 1613. Google Scholar