Articles Vol. 66 No. CĐ14-HNKH BV Giao thông Vận tải 12/01/2026

11. CLINICAL AND PARACLINICAL FEATURES OF LIVER INJURY IN ADULT DENGUE PATIENTS AT VIETNAM TRANSPORT HOSPITAL

Nguyen Thi Phuong Thao1,2, Nguyen Thi Quynh Hoa1,2, Ngo Thi Dung1,2, Le Thi Hong Thang1,2
1 Transport Hospital Joint Stock Company
2 Bệnh viện Giao thông vận tải
Corresponding author: Phuongthaody5@gmail.com
DOI: 10.52163/yhc.v66iCD14.3062
35 Views
20 Downloads
Keywords
Dengue fever, liver injury, transaminases, adults.
Abstract

Objective: To describe the clinical and paraclinical features of liver injury and evaluate treatment outcomes in adult dengue patients at Vietnam Transport Hospital.
Methods: A retrospective cross-sectional study was conducted on 89 patients aged ≥18 years, diagnosed with dengue fever (positive NS1 or IgM Dengue), admitted between June and November 2023. Patients with chronic liver disease, hematologic disorders, hepatotoxic drug use, or admission after day 6 of illness were excluded. Clinical and laboratory data were collected and analyzed.
Results: Right upper quadrant pain occurred in 23.6%, hepatomegaly in 5.6%, jaundice in 1.1%, and no hepatic encephalopathy was recorded. AST and ALT elevations were mostly mild–moderate: AST 2–5×ULN (31.5%), 5–15×ULN (61.8%); ALT 2–5×ULN (55.1%), 5–15×ULN (37.1%). Hyperbilirubinemia (>17 µmol/L) was found in 2.2% and PT% <70 in 1.1%. Mean hospital stay was 5.1 days; 96.6% recovered with no deaths.
Conclusion: Liver injury in dengue fever is mainly characterized by mild–moderate transaminase elevation, with rare cholestasis and coagulopathy. Recovery rate was high, with an average hospital stay of 5 days.

References
[1]
World Health Organization. Dengue and severe dengue. Geneva: WHO; 2023. Google Scholar
[2]
World Health Organization. Dengue: guidelines for diagnosis, treatment, prevention and control. Geneva: WHO; 2022. Google Scholar
[3]
Bộ Y tế. Hướng dẫn chẩn đoán và điều trị sốt xuất huyết Dengue. Hà Nội: Bộ Y tế; 2023. Google Scholar
[4]
Juneja D, et al. Acute liver failure due to dengue virus infection in adults: a multicenter prospective study. J Clin Virol. 2024;168:105423. Google Scholar
[5]
Fernando S, et al. Patterns and causes of liver involvement in dengue infection. BMC Infect Dis. 2016;16:319. Google Scholar
[6]
Teerasarntipan J, et al. Prognostic factors of severe dengue in adults: a multicenter study in Thailand. Am J Trop Med Hyg. 2020;103(4):1714–1721. Google Scholar
[7]
Campana B, et al. Liver involvement in dengue: a systematic review and meta-analysis. PLoS Negl Trop Dis. 2024;18(3):e0012345 Google Scholar