Articles Vol. 66 No. CĐ8-NCKH 19/08/2025

51. EFFECTIVENESS OF METHADONE TREATMENT IN THU DAU MOT CITY, BINH DUONG PROVINCE IN 2024: A COMBINED ASSESSMENT OF SOCIAL IMPACT AND TREATMENT OUTCOMES

Truong Thanh Yen Chau1,2, Nguyen Hong Phuc1,2, Nguyen Mai Vy3,4, Tran Minh Hoang5,6
1 Thu Dau Mot City Medical Center
2 Trung tâm Y tế thành phố Thủ Dầu Một, Tp.Hồ Chí Minh
3 University of Medicine and Pharmacy at Ho Chi Minh City
4 Đại học Y Dược thành phố Hồ Chí Minh
5 Food Safety Department of Ho Chi Minh City
6 Sở An toàn thực phẩm thành phố Hồ Chí Minh
Corresponding author: yenchau.040383@gmail.com
DOI: 10.52163/yhc.v66iCD8.3007
23 Views
8 Downloads
Abstract

Background: Opioid addiction poses a significant public health challenge. Evaluating the effectiveness of methadone substitution therapy (MST) in both social and clinical domains is crucial for developing targeted interventions.

Objective: This study aimed to assess the effectiveness of MST for opioid addiction at the Methadone Treatment Facility in Thu Dau Mot City in 2024.

Methods: A cross-sectional descriptive study was conducted, employing structured questionnaires and medical record reviews of 133 patients who had received MST for at least nine months at the facility.

Results: Social Impact: After nine months of treatment, the proportion of patients with stable employment significantly increased from 29.3% to 70.6% (p<0.001), while the unemployment rate decreased from 24.1% to 3.0% (p<0.001). No instances of legal infractions were reported during the treatment period (p<0.001), and 97% of patients reported improved social relationships with family and friends.

Treatment Outcomes: While treatment adherence was 100%, only 55.6% of patients achieved optimal treatment outcomes. Patients responding positively to treatment were 1.6 times more likely to achieve these outcomes compared to non-responders (p=0.015).

Conclusion and Recommendations: MST demonstrates a positive impact on social reintegration and treatment adherence. However, the relatively low rate of optimal treatment outcomes, primarily attributed to opioid relapse, necessitates enhanced interventions. Strengthening patient counseling and education on relapse prevention, fostering healthy lifestyle skills, promoting social engagement, and addressing high-risk relationships are crucial. These interventions should be particularly emphasized for patients showing suboptimal treatment response.

References
[1]
Phúc ND, Thượng NV, Nghĩa KV, Tú LN, Thành NVN, Thủ LQ, et al. Tham gia điều trị bằng thuốc thay thế Methadone và các yếu tố liên quan trên nhóm nam nghiện chích ma túy tại 3 tỉnh vùng Đông Nam Bộ năm 2021. Tạp chí Y học Dự phòng. 2022;32(4 Phụ bản):183-90. Google Scholar
[2]
Quyết định số 3140/QĐ-BYT ngày 30 tháng 8 năm 2010 của Bộ Y tế về việc Ban hành “Hướng dẫn điều trị thay thế nghiện các chất dạng thuốc phiện bằng thuốc Methadone”. Google Scholar
[3]
Bộ Y tế. Mở rộng việc cấp phát thuốc methadone nhiều ngày ra toàn quốc [Available from: https://moh.gov.vn/tin-noi-bat/-/asset_publisher/3Yst7YhbkA5j/content/mo-rong-viec-cap-phat-thuoc-methadone-nhieu-ngay-ra-toan-quoc. Google Scholar
[4]
Dương VH, Nguyễn TDT, Huỳnh LND, Lê MH, Nguyễn CT. TÌNH HÌNH TUÂN THỦ ĐIỀU TRỊ VÀ MỘT SỐ YẾU TỐ LIÊN QUAN TRÊN BỆNH NHÂN SỬ DỤNG METHADONE TẠI TỈNH VĨNH LONG NĂM 2023. Tạp chí Y Dược học Cần Thơ. 2024(75):21-7. Google Scholar
[5]
Yên HB, Sơn LT, Anh PH, Hiền HT, Mạnh PĐ. Kết quả điều trị thay thế chất dạng thuốc phiện bằng thuốc methadone tại tuyến xã miền núi tỉnh Thanh Hóa, 2017. Tạp chí Y học Dự phòng. 2021;31(3):138-45. Google Scholar
[6]
Le UTN, Tran TT, Le GT, Thai TT. Methadone maintenance treatment in Ho Chi Minh City, Vietnam: Multidimensional measure of adherence and associated factors. Global Public Health. 2022;17(2):313-23. Google Scholar
[7]
Nguyễn HC, Huỳnh MC, Lê NĐK, Huỳnh AP, Nguyễn TQ. TÌNH HÌNH DUY TRÌ ĐIỀU TRỊ METHADONE VÀ CÁC YẾU TỐ LIÊN QUAN Ở BỆNH NHÂN TẠI CÁC CƠ SỞ ĐIỀU TRỊ METHADONE TẠI TỈNH BÌNH DƯƠNG NĂM 2023. Tạp chí Y học Việt Nam. 2024;538(2). Google Scholar
[8]
NIDA. How effective are medications to treat opioid use disorder?. National Institute on Drug Abuse website. https://nida.nih.gov/publications/research-reports/medications-to-treat-opioid-addiction/efficacy-medications-opioid-use-disorder. December 3, 2021 Accessed October 21, 2024. [ Google Scholar
[9]
Amato L, Davoli M, Perucci C, Ferri M, Faggiano F, Mattick R. Amato L, Davoli M, Perucci CA, Ferri M, Faggiano F, Mattick RP. An overview of systematic reviews of the effectiveness of opiate maintenance therapies: available evidence to inform clinical practice and research. J Subst Abuse Treat 28: 321-329. Journal of substance abuse treatment. 2005;28:321-9. Google Scholar
[10]
Baharom N, Hassan MR, Ali N, Shah SA. Improvement of quality of life following 6 months of methadone maintenance therapy in Malaysia. Substance Abuse Treatment, Prevention, and Policy. 2012;7(1):32. Google Scholar
[11]
Sharma V, Chamroonswasdi K, Srisorrachatr S. RATE OF ADHERENCE TO AND FACTORS ASSOCIATED WITH METHADONE MAINTENANCE TREATMENT PROGRAM (MMTP) COMPLIANCE AMONG INJECTING DRUG USE PATIENTS IN NEPAL. Southeast Asian J Trop Med Public Health. 2016;47(2):287-98. Google Scholar
[12]
Lucas GM, Mullen BA, McCaul ME, Weidle PJ, Hader S, Moore RD. Adherence, Drug Use, and Treatment Failure in a Methadone-Clinic–Based Program of Directly Administered Antiretroviral Therapy. AIDS Patient Care and STDs. 2007;21(8):564-74. Google Scholar
[13]
Tran BX, Nguyen LH, Tran TT, Latkin CA. Social and structural barriers for adherence to methadone maintenance treatment among Vietnamese opioid dependence patients. PLOS ONE. 2018;13(1):e0190941. Google Scholar