Articles Vol. 66 No. VoL 66. English Version No 1, 2025 15/08/2025

3. INVESTIGATION OF BK VIRUS INFECTION CHARACTERISTICS IN PATIENTS WITH END-STAGE CHRONIC KIDNEY DISEASE BEFORE KIDNEY TRANSPLANTATION AT MILITARY HOSPITAL 103

Duc Nguyen Van1, Nhat Vo Van2, Su Hoang Xuan2, Ben Nguyen Huu2, Phuong Nguyen Minh2, Giang Ngo Truong2, Thang Le Viet1, Van Diem Thi1, Ha Nguyen Thi Thu1, Kham Hoang Phuc1, Toan Pham Quoc1
1 Military Hospital 103
2 Vietnam Military Medical University
Corresponding author: toannephro@gmail.com
DOI: 10.52163/yhc.v66ienglish.2735
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Abstract

Objectives: Investigate BK (Human polyomavirus) virus infection characteristics and their association with selected clinical and subclinical features in end-stage renal disease patients before kidney transplantation.

Patients and methods: A cross-sectional study, including 80 kidney transplant patients and 80 healthy kidney donors at Military Hospital 103. Venous blood samples were collected and anticoagulated with ethylenediaminetetraacetic acid (EDTA). BK-IgG antibodies were detected using the ELISA kit.

Results and discussions: In a cohort of 80 patients with end-stage chronic kidney disease, 21.3% (17/80) tested seropositive for BK-IgG, while 78.7% (63/80) were seronegative, showing no significant difference compared to the healthy control group. The prevalence of BK virus seropositivity was not significantly associated with age, gender, body mass index (BMI), etiology of renal failure, duration of dialysis, pre-transplant dialysis modality, or anemia status.

 Conclusion: Latent BK virus infection was detected at a significant prevalence using serological methods in end-stage chronic kidney disease patients before kidney transplantation.

Keywords
Kidney transplantation BK virus BK-IgG clinical paraclinical.
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