Articles Vol. 63 No. 1 (2022) 06/01/2022

FACTORS RELATED TO ANTIBIOTIC-ASSOCIATED DIARRHEA AMONG CHILDREN UNDER 6 YEARS OLD AT THE NATIONAL CHILDREN’S HOSPITAL

Ngo Anh Vinh1,2, Do Minh Loan1,2, Pham Thi Mai Huong1,2, Le Thi Huan1,2, Dang Thi Hong Khanh1,2, Nguyen Thi Loan1,2, Trinh Tuan Anh1,2, Nguyen Thi Thu1,2, Truong Manh Tu1,2, Do Thi Xuan1,2, Nguyen Thi Oanh1,2, Nguyen Van Khiem3,4
1 National Children’s Hospital
2 Bệnh viện Nhi Trung ương
3 Vietnam University of Traditional Pharmacy and Medicine
4 Học viện Y học cổ Truyền Việt Nam
Corresponding author: vinhinc@yahoo.com
DOI: 10.52163/yhc.v63i1.269
31 Views
0 Downloads
Abstract

Objectives: Identify some factors related to diarrhea after using antibiotics. Methods: A cross-sectional descriptive study with 236 children under 6 years of age with diarrhea after taking antibiotics treatment at the National Children's Hospital from October 2017 to September 2018. Results: Common age is 7-24 months. The main antibiotic used is Cephalosporin. The time to end diarrhea symptoms was different between the group with and without inpatient treatment at the primary level (p<0.05). The mean  duration to end diarrhea symptoms significant associated with groups with other infections (p<0.05). Conclusion: The duration of diarrhea symptoms associated with the history of treatment at the primary level and associated infection groups.

References
[1]
D’Ostroph AR, So TY, Treatment of pediatric Clostridium difficile infection: a review on treatment efficacy and economic value, Infection and Drug Resistance, 2017; 10:365–75. Google Scholar
[2]
Turck D, Bernet J, Marx J et al., Incidence and risk factors of oral antibiotic-associated diarrhea in an outpatient pediatric population, Journal of Pediatric Gastroenterology and Nutrition, 2003; 37(1), 22-26. Google Scholar
[3]
Tyler Y, Ran D, Goldman, Probiotics for antibiotic-associated diarrhea in children, Canadian Family Physician, 2020; 66(1): 37–39. Google Scholar
[4]
Wistrom J, Frequency of antibiotic-associated diarrhoea in 2462 antibiotic-treated hospitalized patients: a prospective study, Journal of Antimicrobial Chemotherapy, 2001; 47(1): 43-50. Google Scholar
[5]
Guo Q, Goldenberg JZ, Humphrey C et al., Probiotics for the prevention of pediatric antibiotic-associated diarrhea, Cochrane Database of Systematic Reviews, 2019; 30;4(4):CD004827. Google Scholar
[6]
Mantegazza C, Molinari P, D’Auria E et al., Probiotics and antibiotic-associated diarrhea in children: a review and new evidence on Lactobacillus rhamnosus GG during and after antibiotic treatment, Pharmacological Research, 2018; 128:63–72. Google Scholar
[7]
Musher DM, Lorgan N, Mehendiratta V et al., Clostridium difficile colitis that fails conventional metronidazole therapy: response to nitazoxanide, Journal of Antimicrobial Chemotherapy, 2007; 59, 705-710. Google Scholar
[8]
McFarland LV, Beneda HW, Clarridge JE et al., Implications of the changing face of C. difficile disease for health care practitioners. Am. J. Infect. Control, 2007; 35(4), 237-253. Google Scholar
[9]
Damrongmanee A, Ukarapol N, Incidence of antibiotic-associated diarrhea in a pediatric ambulatory care setting. Journal of the Medical Association of Thailand, 2007; 90(3), 513-517. Google Scholar
[10]
Naflesia BOC , Luciano APF, Francisco JP et al., A randomized formula controlled trial of Bifidobacterium lactis and Streptococcus thermophilus for prevention of antibiotic-associated diarrhea in infants, Journal of Clinical Gastroenterology, 2005; 39(5):385-9. Google Scholar