Articles Vol. 66 No. 3 26/05/2025

5. EVALUATION OF LIVER AND KIDNEY FUNCTIONS IN HIV PATIENTS UNDERGOING ARV TREATMENT AT THU DUC CITY HOSPITAL DURING THE PERIOD 2023-2024 AND ASSOCIATED FACTORS

Tran Nguyen Ai Thanh1,2
1 Thu Duc city Hospital
2 Bệnh viện thành phố Thủ Đức
Corresponding author: aithanh.trannguyenbvtd@gmail.com
DOI: 10.52163/yhc.v66i3.2496
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Keywords
HIV kidney function liver function kidney dysfunction elevated liver enzymes
Abstract

Objective: Evaluated the liver and kidney functions of HIV patients undergoing ARV at Thu Duc city Hospital during the period from 2023 to 2024 and to identify the factors associated with kidney dysfunction and elevated liver enzymes.

Methods: This retrospective, descriptive study was conducted at the Infectious Diseases Unit, Department of Internal Medicine, Thu Duc city Hospital with participating of 235 HIV patients who met the study inclusion criteria. Blood tests, including ALT, AST, and creatinine, were assessed before and one year after starting ARV treatment.

Results: The study found that after one year of ARV treatment, there was an increase in the incidence of kidney dysfunction, with the proportion of patients with normal kidney function decreasing from 74.5% to 66.8%. Additionally, the percentage of patients with elevated liver enzymes slightly increased from 11.5% to 12.8%. Gender and cardiovascular disease were statistically significant factors associated with kidney dysfunction (p < 0.05). However, no significant associations were found between other factors, such as age, location, or respiratory diseases, and liver function impairment.

Conclusion: After one year of ARV treatment, there is an increased risk of kidney dysfunction and a slight increase in liver enzyme abnormalities in HIV patients. Monitoring and managing these functions are essential during ARV therapy, especially in male patients and those with cardiovascular conditions.

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