Articles Vol. 66 No. CĐ7-HNKH Bệnh viện K 22/05/2025

19. QUALITY OF LIFE IN BREAST CANCER PATIENTS TREATED WITH ADJUVANT CHEMOTHERAPY AT VIETNAM NATION NATIONAL CANCER HOSPITAL IN 2024

Nguyen Thi Nhan1,2, Phan Ngoc Huyen1,2, Phung Thi Huyen1,2, Dang Tien Giang1,2
1 Vietnam Nation National Cancer Hospital
2 Bệnh viện K
Corresponding author: bsđtgiang@gmail.com
DOI: 10.52163/yhc.v66iCD7.2400
33 Views
18 Downloads
Keywords
breast cancer QoL QLQ-C30 QLQ-BR23
Abstract

Objective: To describe the quality of life (QoL) of breast cancer patients treated with adjuvant chemotherapy following radical breast cancer surgery at K Hospital in 2024.

Subjects and Research Methods: A prospective descriptive study was conducted from April 2024 to November 2024 with 85 early-stage breast cancer patients who received adjuvant chemotherapy after radical surgery. Quality of life scores were assessed using the EORTC QLQ-30 and QLQ-BR23 scales from the European Organization for Research and Treatment of Cancer. QoL was evaluated at different time points before chemotherapy and after treatment.

Results:

  • QLQ-30 QoL Scores at the time of treatment completion: The overall QoL score was 67.5, with social functioning having the highest score (86.7) and physical functioning the lowest (75.3). The general symptom domain scored 23.2, with the most bothersome symptoms being fatigue (35.6), pain (29.4), and loss of appetite (28.3). Financial impact was also a significant concern, with a score of 27.6.
  • QLQ-BR23 Scores at the time of treatment completion: The future perspective scored the highest at 66.8. In terms of symptom domains, systemic side effects scored 24.3, arm symptoms 15.6, and breast symptoms 12.8. Statistically significant differences in QoL, both in functioning and symptoms, were observed between patients before treatment, after 3-4 cycles, and after completing treatment.

Conclusion: These findings provide multidimensional insights into the side effects and toxicity of chemotherapy, as well as the physical and mental health of patients during treatment. This information can guide appropriate communication strategies, emotional support, and assist patients in developing optimal treatment plans.

References
[1]
Bray F, Laversanne M, Sung H, et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2024; 74(3): 229-263. doi:10.3322/caac.21834 Google Scholar
[2]
Stavrou D, Weissman O, Polyniki A, et al. Quality of Life After Breast Cancer Surgery With or Without Reconstruction. Eplasty. 2009;9:e18. Google Scholar
[3]
Aaronson NK, Ahmedzai S, Bergman B, et al. (1993). The European Organization for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology. J Natl Cancer Inst. 85(5), pp. 365-376 Google Scholar
[4]
The World Health Organization Quality of Life assessment (WHOQOL): position paper from the World Health Organization. Soc Sci Med 1982. 1995;41(10):1403-1409. doi:10.1016/0277-9536(95)00112-k Google Scholar
[5]
Nguyễn Thị Kim Tuyến. Chất lượng sống của bệnh nhân ung thư vú từ nghiên cứu đến thực tiễn. Tạp chí Phụ sản. 2014 Google Scholar
[6]
Dewolf L, Koller M, Velikova G, et al (2009). "EORTC Quality of Life Group translation procedure". (3rd ed.) Brussels, Belgium: EORTC Quality of Life Group, pp.32 Google Scholar
[7]
Fayers P, Bottomley A; EORTC Quality of Life Group; Quality of Life Unit. Quality of life research within the EORTC-the EORTC QLQ-C30. European Organisation for Research and Treatment of Cancer. Eur J Cancer. 2002 Mar;38 Suppl 4:S125-33. doi: 10.1016/s0959-8049(01)00448-8. PMID: 11858978. Google Scholar
[8]
Sprangers MA, Groenvold M, Arraras JI, Franklin J, te Velde A, Muller M, Franzini L, Williams A, de Haes HC, Hopwood P, Cull A, Aaronson NK. The European Organization for Research and Treatment of Cancer breast cancer-specific quality-of-life questionnaire module: first results from a three-country field study. J Clin Oncol. 1996 Oct;14(10):2756-68. doi: 10.1200/JCO.1996.14.10.2756. PMID: 8874337. Google Scholar
[9]
Trần Thu Uyên và cộng sự. KHẢO SÁT SỰ THAY ĐỔI CHẤT LƯỢNG CUỘC SỐNG Ở BỆNH NHÂN UNG THƯ VÚ ĐIỀU TRỊ TẠI BỆNH VIỆN TRUNG ƯƠNG THÁI NGUYÊN. TNU Journal of Science and Technology 228(05): 478 – 484 Google Scholar
[10]
Montazeri, A., Vahdaninia, M., Harirchi, I. et al. Quality of life in patients with breast cancer before and after diagnosis: an eighteen months follow-up study. BMC Cancer 8, 330 (2008). https://doi.org/10.1186/1471-2407-8-330 Google Scholar