Articles Vol. 62 No. 7 (2021) 09/12/2021

CHARACTERISTICS AND THE EFFECTIVENESS OF ANTENATAL SCREENING FOR CHRONMOSOMAL ABNORMALITIES IN HIGH-RICK PREGNANT WOMAN IN NGHE AN (2020 – 2021)

Tang Xuan Hai1,2, Que Anh Tram3,4
1 Nghe An Obstetric and Pediatrics Hospital
2 Bệnh viện Sản Nhi Nghệ An
3 Nghe An Priendship General Hospital
4 Bệnh viện Hữu nghị Đa khoa Nghệ An
Corresponding author: bstangxuanhai@gmail.com
DOI: 10.52163/yhc.v62i7 (2021).240
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Keywords
Chromosomal abnormalities, amniocentesis, pregnancy.
Abstract

Characteristics and the effectiveness of antenatal screening for chromosomal abnormalities in high-risk pregnant women in Nghe An (2020 – 2021), Screening for fetal chromosomal abnormalities is of great significance in limiting birth defects.

Objective and method: To figure out chromosomal abnormalities and the value of some prenatal screening tests at Nghe An Obstetrics and Gynecology Hospital (2020-2021). Methods: 121 pregnant women who had an indication for amniocentesis were undergone ultrasound, Double test, Triple test and amniocentesis for a karyotype analysis.

Results: The mean age of the participants was 32 ± 6.69 years. 62.8% of fetuses had abnormalities on ultrasound, among them the most common ones were nuchal translucency thickness (12.6%) and aplasia of the nasal bone (5.5%). The rate of chromosomal abnormality was 15.7%, of which the most common was Edwards syndrome (36.8%) followed by Down syndrome (31.6%).There was no association between fetal chromosomal abnormalities and maternal age of the pregnancy, history of pregnancy with malformations, miscarriage or family history of genetic disease.

Conclusion: Ultrasound and blood screening tests have high sensitivity, high negative predictive value but low sensitivity and low positive predictive value in predicting abnormalities of fetal chromosomes.

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