Articles Vol. 66 No. CĐ7-HNKH Bệnh viện K 22/05/2025

15. THE RELATIONSHIP BETWEEN NUTRITION AND SOME SIDE EFFECTS OF HIGH-DOSE METHOTREXATE ON BONE CANCER PATIENTS AT THE PEDIATRIC DEPARTMENT OF K HOSPITAL

Nguyen Dinh Le1,2, Nguyen Thi Binh3,4
1 Hanoi Medical University
2 Đại học Y Hà Nội
3 Department of Pediatrics, K Hospital
4 Khoa Nội Nhi Bệnh Viện K
Corresponding author: thaobinhnguyen190586@gmail.com
DOI: 10.52163/yhc.v66iCD7.2396
19 Views
15 Downloads
Keywords
nutrition high-dose methotrexate bone cancer
Abstract

Objective: This study aims to describe some adverse effects of high-dose Methotrexate regimen in patients with bone cancer and to explore on the relationship between nutritional status and these adverse effects.

Materials and methods: A cross-sectional study using a pre-designed questionnaire was conducted in 42 bone cancer patients receiving high-dose Methotrexate at the Pediatric Department of K Hospital, from April 2024 to October 2024.

Results: The most common age group for bone cancer was between 10-20 years, comprising 78.4% of the sample, with a higher percentage of male patients (57.1%). Most patients (74.8%) were from rural or mountainous areas. At diagnosis, 21.4% of patients had metastasis, and 33.3% experienced underweight or malnutrition during treatment. The most prevalent clinical symptoms included vomiting, nausea, loss of appetite, and hair loss, which were reported by 81% of patients. Diarrhea was noticed in 19% of patients, while 90.5% of them had leucopenia. Methotrexate toxicity was observed in 52.4% of patients. The malnourished group had higher rates of oral mucositis and MTX toxicity than the healthy group (p values ​​are 0.026 and 0.03, respectively).

Conclusion: Patients with bone sarcoma have a high rate of malnutrition at 33.3%. Nutritional status was significantly associated with the adverse effects of MTX, namely stomatitis and methotrexate toxicity.

References
[1]
Dũng LC. Bướu xương: Lâm sàng - hình ảnh y học, giải phẫu bệnh và điều trị. In: Sacoom Tạo Xương. Nhà xuất bản Y học; 2003. Google Scholar
[2]
Minh NT. Nhận xét về đặc điểm lâm sàng, X quang, mô bệnh học và kết quả điều trị ung thư xương nguyên phát tại bệnh viện K. In: Trường Đại học Y Hà Nội; 2000. Google Scholar
[3]
Whelan JS, Bielack SS, Marina N, et al. EURAMOS-1, an international randomised study for osteosarcoma: results from pre-randomisation treatment. Ann Oncol Off J Eur Soc Med Oncol. 2015;26(2):407-414. Google Scholar
[4]
Phương PĐ, Kiên ĐH. Kết quả điều trị Sarcoma xương giai đoạn II bằng hóa chất phác đồ MAP bổ trợ trước phẫu thuật tại Bệnh viện K. VMJ. Published online 2022. Google Scholar
[5]
Rawat N, Chanu SE, Chauhan V. Chemotherapy Associated Side Effects among Children with Cancer. Int J Health Sci Res. 2021;11(2):236-242. Google Scholar
[6]
Sanguanboonyaphong P, Komvilaisak P, Suwannaying K, et al. Predictors of Chemotherapy Induced Adverse Events in Pediatric Osteosarcoma Patients. Asian Pac J Cancer Prev APJCP. 2022;23(1):93-100. Google Scholar
[7]
Hải TTT. Đặc điểm lâm sàng, cận lâm sàng và tác dụng phụ của Methotrexate liều cao trong điều trị Sarcoma xương tại Bệnh viện K. Đại Học Hà Nội. Published online 2019. Google Scholar
[8]
Özalp Gerçeker G, Yildirim BG, Arıcıoğlu Sülün A, Bektaş M, Hekimci Özdemir H, Malbora B. The effect of chemotherapy on symptoms and nutritional status in children with cancer. Eur J Oncol Nurs Off J Eur Oncol Nurs Soc. 2022;61:102206. Google Scholar