Articles Vol. 66 No. 2 04/03/2025

23. RELATIONSHIP BETWEEN THE ALBUMIN-GLOBULIN SCORE AND PROGNOSTIC BIOCHEMICAL MARKERS IN MULTIPLE MYELOMA PATIENTS

Vu Duc Binh1,2, Nguyen Thi Huyen3,4,5,6, Vu Thi Mai4,6
1 National Institute of Hematology and Blood Transfusion
2 Viện Huyết học- Truyền máu Trung ương
3 Hanoi Medical University
4 Phu Tho Provincial General Hospital
5 Trường Đại học Y Hà Nội
6 Bệnh viện đa khoa tỉnh Phú Thọ
Corresponding author: bshuyenpt@gmail.com
DOI: 10.52163/yhc.v66i2.2085
14 Views
18 Downloads
Keywords
Multiple myeloma albumin-globulin score prognostic factor
Abstract

Objective: To analyze the relationship between certain biochemical markers and the Albumin-Globulin Score (AGS).

Subject and method: This descriptive analytical study was conducted on 98 newly diagnosed multiple myeloma (MM) patients from 2022 to 2024 at the National Institute of Hematology and Blood Transfusion.

Results: The study population had a mean age of 64.7 years, with 44.9% being male. There were no statistically significant differences in age or gender across the different AGS groups. Albumin levels showed a decreasing trend as AGS increased (from 41.5 to 27.8), while globulin levels increased significantly from 29.2 to 90.5 with higher AGS scores (p < 0.05). Levels of β2-microglobulin (β2M), creatinine, calcium, and lactate dehydrogenase (LDH) did not differ significantly across AGS groups. The multivariate regression model for biochemical markers did not achieve statistical significance.

Conclusion: There was no significant association between age, gender and AGS. Albumin was inversely correlated, while globulin was directly correlated with AGS. Levels of β2M, creatinine, calcium, and LDH were consistent across AGS groups.

References
[1]
Phan Nguyễn Thanh Vân, Cao Thị Lộc và Nguyễn Hữu Bền, Đặc điểm các yếu tố tiên lượng bệnh nhân đa u tủy xương. Tạp chí Y học Việt Nam, 2023, 524(1B): Google Scholar
[2]
Đỗ Trung Phấn, Bài giảng huyết học - truyền máu: Sau đại học. Nhà xuất bản Y Học, 2014, Hà Nội, Google Scholar
[3]
Shang‐Yi Huang, Ming Yao, Jih‐Luh Tang et al., Epidemiology of multiple myeloma in Taiwan: increasing incidence for the past 25 years and higher prevalence of extramedullary myeloma in patients younger than 55 years. Cancer: Interdisciplinary International Journal of the American Cancer Society, 2007, 110(4): 896-905. Google Scholar
[4]
Jae Hoon Lee, Dong Soon Lee, Je Jung Lee et al., Multiple myeloma in Korea: past, present, and future perspectives. Experience of the Korean Multiple Myeloma Working Party. International journal of hematology, 2010, 92(52-57. Google Scholar
[5]
Dae Sik Kim, Eun Sang Yu, Ka-Won Kang et al., Myeloma prognostic index at diagnosis might be a prognostic marker in patients newly diagnosed with multiple myeloma. The Korean journal of internal medicine, 2016, 32(4): 711-721. Google Scholar
[6]
Ying Cai, Yu Zhao, Qiuxin Dai et al., Prognostic value of the albumin–globulin ratio and albumin–globulin score in patients with multiple myeloma. Journal of International Medical Research, 2021, 49(3): 0300060521997736. Google Scholar
[7]
S Vincent Rajkumar, Meletios A Dimopoulos, Antonio Palumbo et al., International Myeloma Working Group updated criteria for the diagnosis of multiple myeloma. The lancet oncology, 2014, 15(12): e538-e548. Google Scholar
[8]
Hàn Viết Trung, Nghiên cứu đặc điểm và giá trị của các yếu tố tiên lượng tới kết quả của một số phác đồ điều trị đa u tủy xương từ 2015 - 2018. Luận án tiến sĩ y học, 2021, Đại học y Hà Nội. Google Scholar
[9]
Nguyễn Thùy Dương, Nghiên cứu đặc điểm lâm sàng, cận lâm sàng và kết quả điều trị trong bệnh đa u tủy xương chuỗi nhẹ tại Viện Huyết họcTruyền máu Trung Ương. Luận văn thạc sĩ y học, 2018, Đại học Y Hà Nội. Google Scholar