Articles Vol. 66 No. 2 04/03/2025

48. SURVEY OF ANTI-MULLERIAN HORMONE CONCENTRATION IN INFERTILITY PATIENTS AT THE DEPARTMENT OF ASISTED REPRODUCTIVE THAI NGUYEN A HOSPITAL

Pham Thanh Loan1,2, Ha Hai Bang1,2, Hua Minh Tuan1,2, Ly Thi Bac1,2, Tong Thi Phuong Thao1,2, Than Duc Manh3,4, Huynh Quang Thuan5,6, Hoang Tho Minh5,6
1 Thai Nguyen A Hospital
2 Bệnh viện A Thái Nguyên
3 Thai Nguyen University of Medicine and Pharmacy
4 Trường Đại học Y Dược Thái Nguyên
5 103 Military Hospital
6 Bệnh viện Quân y 103
Corresponding author: minh.hoang937@gmail.com
DOI: 10.52163/yhc.v66i2.2077
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Keywords
AMH ovarian stimulation
Abstract

Objective: To survey AMH levels and determine the response point to ovarian stimulation therapy of AMH levels in infertile and subfertile patients.

Subjects and methods: A cross-sectional study was conducted on 278 female patients of reproductive age (18-45 years old), diagnosed with infertility (primary or secondary) and treated with ovarian stimulation at the Department of Reproductive Support, Thai Nguyen A Hospital.

Results: The average AMH concentration in the study was 3.93 ± 2.89 (ng/mL), the median value was 3.0 ng/mL, the maximum value was 16.7ng/ml and the minimum was 0.243ng/mL. The average AMH concentration and the number of reserve oocytes are inversely proportional to the patient's age, especially after the age of 35, it is only half of that of the age of 19-24. The AMH concentration is moderately positively correlated with the number of oocytes obtained after ovarian stimulation. When the AMH concentration is ≤ 1.1 ng/mL, it shows that the patient responds poorly or almost does not respond to ovarian stimulation. With an AMH concentration = 1.2 ng/mL, the patient responds poorly to ovarian stimulation, an AMH concentration of 3.1-4.4 ng/mL, the patient responds well to ovarian stimulation, greater than 4.5 ng/mL is the threshold value for excessive response to ovarian stimulation.

Conclusions: AMH concentration decreases with age and positively correlates with the number of oocytes obtained after ovarian stimulation. The threshold of AMH that responds well to ovarian stimulation is 4.5 ng/mL.

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