Articles Vol. 66 No. 2 04/03/2025

45. PREGNANCY OUTCOMES IN PATIENTS WITH FROZEN BLASTOCYST TRANSFER USE OF TIME-LAPSE INCUBATOR WITH AND WITHOUT PGT-A AT HANOI OBSTETRICS AND GYNECOLOGY HOSPITAL

Nguyen Thi Thu Ha1,2, Nguyen Duy Anh1,2, Pham Thuy Nga3,4, Be Thi Hoa5,6
1 National Hospital of Obstetrics and Gynecology
2 Bệnh viện Phụ Sản Trung ương
3 Ha Noi Obstetrics and Gynecology Hospital
4 Bệnh viện Phụ sản Hà Nội
5 Thai Nguyen University of Medicine and Pharmacy
6 Trường Đại học Y dược Thái Nguyên
Corresponding author: dr.hanguyen.nhog@gmail.com
DOI: 10.52163/yhc.v66i2.2054
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Keywords
Frozen blastocyst embryoư time-lapse incubatorư PGT-A
Abstract

Objective: To evaluate pregnancy outcomes in patients with frozen blastocyst embryo transfer cultured using the Timelapse system with and without preimplantation genetic testing for aneuploidy (PGT-A) at Hanoi Obstetrics and Gynecology Hospital.

Materials and methods: This cross-sectional descriptive study was conducted on 221 patients who underwent single day-5 frozen embryo transfer using the Timelapse system at Hanoi Obstetrics and Gynecology Hospital, from June 2023 to May 2024.

Results: The rate of bHCG (+), clinical pregnancy rate, and progressive pregnancy in the non-PGT group and the group with normal PGT results were significantly higher than in the group with abnormal PGT results (p< 0.05).. The difference between the 3 groups was not statistically significant (p>0.05). The pregnancy rate in ICM type A (70%; 53.9%; 71.4%) was higher than that in type B (30%; 46.1%; 28.6%) and C (0%; 0%; 0%) in all 3 groups: no PGT, normal PGT and abnormal PGT. The pregnancy rate in TE type A (61.4%) was higher than that in type B (38.6%) and C (0%) in the group that did not do PGT. The pregnancy rate in TE type B (55.3%; 71.4%) was higher than that in type A (36.8%; 28.6%) and C (7.9%; 0%) in both groups that did PGT with normal results and abnormal PGT.

Conclusion: Pregnancy outcomes in patients undergoing day-5 frozen embryo transfer cultured using the Timelapse system without PGT-A or with normal PGT-A results are superior to those with abnormal PGT-A results (p > 0.05).

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