Articles Vol. 66 No. 2 04/03/2025

7. STUDY IN ACUTE TOXICITY AND SUB-CHRONIC TOXICITY OF RAW MATERIALS FOR PRODUCING JASMIN DETOX HARD CAPSULES ON EXPERIMENTAL ANIMALS

Chu Quang Truyen1,2, Do Cong Tuan Nghia2,3, Dang Ngoc Phuong2,3, Nguyen Thi Thuy Trang2,3, Do Thi Thao4,5, Le Hong Manh6,7, Tran Van Thanh8,9, Vo Van Canh10,11, Dinh Thi Van12,13, Le Phuong Quynh1,2, Cam Thi Inh1,2
1 Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology
2 Viện Hóa học các Hợp chất thiên nhiên-Viện Hàn lâm Khoa học và Công nghệ Việt Nam
3 institute of Natural Products Chemistry, Vietnam Academy of Science and Technology
4 Institute of Biotechnology, Vietnam Academy of Science and Technology
5 Viện công nghệ sinh học - Viện Hàn lâm Khoa học và Công nghệ Việt Nam
6 Institute of Physics - Vietnam Academy of Science and Technology
7 Viện Vật Lý- Viện Hàn lâm Khoa học và Công nghệ Việt Nam
8 Vietnam University of Traditional Medicine
9 Đại học Y học cổ truyền Việt Nam
10 National Institute of Hematology and Blood Transfusion
11 Viện Huyết học và Truyền máu Trung Ương
12 Faculty of Pharmacy, Hanoi University of Business and Technology
13 Khoa dược, Trường Đại học kinh doanh và Công nghệ Hà Nội
Corresponding author: quangtruyen69@gmail.com
DOI: 10.52163/yhc.v66i2.2051
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Keywords
Chevang acute toxicity sub-chronic toxicity hematological parameters
Abstract

The toxicity of material M1 used for production of Jasmin detox, a dietary supplement containing powdered Jasminum subtriplinerve, Silybum marianum, Centella asiatica, Solanum procumbens, and Cynara scolymus as main ingredients, has been evaluated in acute and sub-chronic toxicity studies. Acute oral toxicity studies in ICR mice did not detect mortality or treatment-related signs at a dose of 5000 mg/kg/24h for 72h (LD50 >5000 mg/kg). Dose selection for sub-chronic toxicity studies of LD50 (500 mg/kg). After continuous administration of M1 for 28 days at this dose, treated mice presented no significant change in body weight, in daily behaviors and weight of selected organs (liver, spleen, and kidney) as well. The hematological parameters, liver indices (ALT level), renal indices (creatinine level) were not affected. The study showed that materials to produce Jasmin detox capsules are safe to be taken orally at a dose of 500 mg/kg bd.w for 28 days.

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