Articles Vol. 66 No. 2 04/03/2025

2. INTERVENTION TO IMPROVE BONE DENSITY USING VITAMIN K2 SUPPLEMENTS IN POSTMENOPAUSAL WOMEN AGED 45 AND ABOVE IN LAM DONG PROVINCE IN 2023-2024

Dang Ngoc Hung1,2, Nguyen Do Huy3,4, Tran Quoc Cuong5,6, Le Thi Thu Huyen7,8, q1,2, Dinh Thi Thu Hang9,10, Tran Thi Minh Nguyet9,10, Nguyen Nguyen Ngoc11,12
1 Nutrition Research and Consulting Institute NRECI
2 Viện Nghiên cứu và Tư vấn dinh dưỡng NRECI
3 Vietnam National University, Hanoi
4 Đại học Quốc gia Hà Nội
5 Pham Ngoc Thach University of Medicine
6 Trường Đại học Y khoa Phạm Ngọc Thạch
7 Institute of Community Medicine Research and Training MRIT
8 Viện Nghiên cứu và Đào tạo Y học cộng đồng MRIT
9 National Institute of Nutrition
10 Viện Dinh dưỡng Quốc gia
11 Save the Children International in Vietnam
12 Văn phòng đại diện Tổ chức Save the Children International tại Việt Nam
Corresponding author: danghungyhdp@gmail.com
DOI: 10.52163/yhc.v66i2.2036
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Keywords
Bone density reduction nutritional products vitamin K2 postmenopausal women Lam Dong
Abstract

Objectives: To evaluate the effectiveness of improving bone density through supplementation in postmenopausal women aged 45 and above in Lam Dong province in 2023-2024.

Objects and methods: This community intervention study, monitored over 6 months was conducted among postmenopausal women aged 45 and above with osteopenia. The intervention group I received supplements of vitamin K2, calcium, and vitamin D3, while intervention group II received calcium and vitamin D3 supplements.

Results: In intervention group I, the average Osteocalcin index decreased from 21.08 ± 10.39 ng/mL to 18.28 ± 8.08 ng/mL (p < 0.001); similarly, intervention group II also recorded a decrease in Osteocalcin index from 21.42 ± 6.83 ng/mL to 19.29 ± 6.77 ng/mL (p = 0.003). For β-CTX index, intervention group I decreased from 351.27 ± 177.05 ng/mL to 236.78 ± 129.19 ng/mL (p < 0.001); meanwhile, intervention group II decreased from 298.58 ± 141.82 ng/mL to 284.61 ± 170.90 ng/mL, but the difference was not statistically significant (p = 0.568).

Conclusions: Supplementing vitamin K2 combined with calcium and vitamin D3 significantly changed bone turnover markers compared to the group supplementing only calcium and vitamin D3.

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