Articles Vol. 66 No. CĐ1-NCKH 24/01/2025

47. CLINICAL, SUBCLINICAL CHARACTERISTICS OF CHILDREN WITH PNEUMONIA CAUSED BY RESPIRATORY SYNCYTIAL VIRUS BACTERIAL CO-INFECTIONS

Le Thi Hoa1,2, Le Thi Hong Hanh1,2, Phung Thi Bich Thuy1,2, Bui Thi Huyen3,4, Ngo Thi Loan1,2, Do Thi Sen1,2, Le Thanh Chuong1,2, Vu Thi Tâm1,2, Nguyen Thi Van Anh3,4
1 Vietnam National Children’s Hospital
2 Bệnh viện Nhi Trung ương
3 Spobiotic Research Center, ANABIO R&D Ltd. Company
4 Công ty TNHH ANABIO R&D
Corresponding author: hoayhn3004@gmail.com
DOI: 10.52163/yhc.v66iCD1.2021
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Keywords
Pneumonia RSV CRP children
Abstract

Objective: To describe the clinical, subclinical characteristics of children with pneumonia caused by respiratory syncytial virus, bacterial co-infection.

Subjects and methods: A descriptive study was conducted on 283 children aged 1-24 months with respiratory syncytial virus pneumonia who were hospitalized at the Center for Pulmonology and Respiratory Care, Vietnam National Children’s Hospital, from August 2022 to November 2023.

Results: The rate of bacterial co-infection in children with respiratory syncytial virus pneumonia was 57.2%, with a higher prevalence in the 6-11 months age group (p < 0.05). Children with bacterial co-infection were 3.66 times more likely to have fever compared to those without co-infection, with fever rates of 74.7% and 44.6%, respectively (p < 0.05). The bacterial co-infection group also showed a significantly higher prevalence of both dry rales and moist rales (p < 0.05). In terms of subclinical findings, white blood cell count, neutrophil count, and CRP levels were significantly elevated in the co-infection group (p < 0.01). Notably, the risk of elevated CRP levels (≥ 6 mg/dl) was 4.3 folds higher in the bacterial co-infection group compared to the non-co-infection group (95%CI: 2.6-7.2; p < 0.0001).

Conclusion: Bacterial co-infection is common in children with respiratory syncytial virus pneumonia and is associated with more severe clinical manifestations, including fever, dry rales and moist rales, as well as elevated white blood cell counts and CRP levels

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