Articles Vol. 66 No. CĐ1-NCKH 24/01/2025

44.VALUE OF PHIGFBP-1 TEST IN PREDICTING PREMATURE LABOR AT NATIONAL HOSPITAL OF OBSTETRICS AND GYNECOLOGY

Hoang Phuong Thao1,2, Pham Hai Ha1,2, Nguyen Thi Huyen Linh1,2
1 National Hospital of Obstetrics and Gynecology
2 Bệnh viện Phụ Sản Trung ương
Corresponding author: huyenlinhpstw@gmail.com
DOI: 10.52163/yhc.v66iCD1.2016
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Keywords
PhIGFBP-1 pre-term birth
Abstract

Objective: To describe the result of PhIGFBP-1 test in the diagnosis of pre-term birth at the National Hospital of Obstetrics and Gynecology.

Methodology: A cross-sectional and prospective descriptive study was conducted. Testing PhIGFBP-1 was performed on 158 pregnant women with a diagnosis of threatened preterm labor admitted to the Department of Obstetrics Pathology, National Hospital of Obstetrics and Gynecology, followed up for 14 days and recorded whether patients gave birth or not within 14 days.

Results: 33 out of 158 pregnant women had preterm birth, of which 21 pregnant women (13.3%) had preterm birth within 7 days of admission, and 12 pregnant women (7.6%) had preterm birth within the next 7-14 days. The sensitivity, specificity, positive diagnostic value, and negative diagnostic value of the PhIGFBP-1 test were 75.8%, 77.6%, 47.2%, and 92.4%, respectively.

Conclusions: The test to determine the presence of PhIGFBP-1 in cervical fluid has high value in the diagnosis in cases of preterm pregnancy with patients having signs of threatened preterm labor. It can be considered as a screening measure to limit and minimize unnecessary medical interventions in preterm pregnant women

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