Articles Vol. 66 No. CĐ1-NCKH 24/01/2025

12. CLINICAL AND PARACLINICAL CHARACTERISTICS OF THE GROUP OF PATIENTS WHO HAD FROZEN EMBRYO TRANSFER USING TIMELAPSE SYSTEM FOR EMBRYO INCUBATION

Pham Thuy Nga1,2, Nguyen Thi Thu Ha3,4, Nguyen Thi My Dung1,2, Nguyen Thi Linh1,2, Be Thi Hoa5,6
1 Hanoi Hospital of Obstetric and Gynecology
2 Bệnh viện Phụ Sản Hà Nội
3 . National Hospital of Obstetric and Gynecology
4 Bệnh viện Phụ sản Trung ương
5 Thai Nguyen University of Medicine and Pharmacy
6 Trường Đại học Y Dược Thái Nguyên
Corresponding author: flowerflower.dr@gmail.com
DOI: 10.52163/yhc.v66iCD1.1974
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Keywords
Timelapse embryo incubation
Abstract

Objectives: To review of clinical and paraclinical characteristics of the group of patients who had frozen embryo transfer using timelapse system for embryo incubation.

Subjects and methods: Cross-sectional descriptive study on 118 cases of embryo culture using Timelapse monitoring system at the Department of Assisted Reproduction and Andrology, Hanoi Obstetrics and Gynecology Hospital from December 2023 to May 2024.

Results: The average age of the wife was 31.9 ± 4.6 years; the average duration of infertility was 2.84 ± 2.2 years, the group of infertility under 5 years accounted for the highest rate of 80.4%. 86.8% of patients had experienced two or more miscarriages or stillbirths in their past. At the start of the cycle, the average concentration of FSH was 6.75 ± 3.15 mIU/mL. 3.84 ± 2.61 ng/mL was the average AMH levels. 14.01 ± 7.11 antral follicles on average were present. There was no decline in ovarian reserve in 91.5% of patients.

Conclusions: Timelapse is the preferred option for patients with a history of multiple miscarriages or stillbirths, recurrent implantation failure, and normal endocrine and ovarian reserve characteristics.

References
[1]
1. Hồ Mạnh Tường, Đặng Quang Vinh, Vương Thị Ngọc Lan, Thụ tinh trong ống nghiệm, Nhà xuất bản Tổng hợp thành phố Hồ Chí Minh, 2023. Google Scholar
[2]
2. ESHRE Working group on Time-lapse technology, Apter S, Ebner T, Freour T, Guns Y, Kovacic B, et al, Good practice recommendations for the use of time-lapse technology†, Hum Reprod Open. 2020 Feb 1, 2020 (2): hoaa008. Google Scholar
[3]
3. Bladh Blomquis A, Samir R, Engstrom A.B, Nilsson S, Lind A.K, Westlander G et al, Patients experience of viewing time-lapse sequences: A prospective survey study, Gynecol Reprod Endocrinol, 2017, 01 (01), doi:10.35841/2591-7994.1.1.1-6 Google Scholar
[4]
4. Diêm Thị Yến, Lê Thị Phương Lan, Nguyễn Thị Cẩm Vân, Nguyễn Thị Như Trang, Trần Huệ Trân, Trương Văn Hạnh, Khuất Hữu Quân, Nguyễn Vũ Hà, Vũ Văn Thành, Vũ Thị Liên, Kết quả lâm sàng của các trường hợp chuyển một phôi nang qua phương pháp nuôi cấy Timelapse tại Trung tâm Hỗ trợ sinh sản Vinmec Times City, Tạp chí Y học Việt Nam, 2022, 510 (1). Google Scholar
[5]
5. Lê Hoàng Anh, Hiệu quả sử dụng Timelapse trong lựa chọn phôi chuyển tại IVFMD Phú Nhuận, Hội nghị vô sinh và kỹ thuật hỗ trợ sinh sản lần 8, 2019. Google Scholar
[6]
6. Insua M.F, Cobo A.C, Larreategui Z, Ferrando M, Serra V, Meseguer M, Obstetric and perinatal outcomes of pregnancies conceived with embryos cultured in a time-lapse monitoring system, Fertil Steril, 2017 Sep, 108 (3): 498-504. Google Scholar
[7]
7. Lee C.I, Wu C.H, Pai Y.P, Chang Y.J, Chen C.I, Lee T.H et al, Performance of preimplantation genetic testing for aneuploidy in IVF cycles for patients with advanced maternal age, repeat implantation failure, and idiopathic recurrent miscarriage, Taiwan J Obstet Gynecol, 2019 Mar, 58 (2): 239-43. Google Scholar
[8]
8. Ma B.X, Zhang H, Jin L, Huang B, Neonatal Outcomes of Embryos Cultured in a Time-Lapse Incubation System: an Analysis of More Than 15,000 Fresh Transfer Cycles, Reprod Sci Thousand Oaks Calif, 2022 May, 29 (5): 1524-30. Google Scholar
[9]
9. Esteves S.C, Andersen C.Y, Fischer R, Humaidan P, Alviggi C, Editorial: POSEIDON’s Stratification of ‘Low Prognosis’ Patients in ART: The WHY, the WHAT, and the HOW. Front Endocrinol [Internet] , 2021 [cited 2024 Sep 18];12. Available from: https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2021. 719647. Google Scholar