Articles Vol. 66 No. CĐ1-NCKH 24/01/2025

2. VALIDATION OF HIGH PERFORMANCE LIQUID CHROMATOGRAPHY METHOD FOR THE DETERMINATION OF MELOXICAM IN ANTI-INFLAMMATORY FILM

Nguyen Van Bach1,2, Bui Thi Tra My1,2, Trinh Nam Trung1,2, Nguyen Truong Toan1,2, Nguyen Thi Hong Van1,2, Cao Van Anh1,2
1 Vietnam Military Medical University
2 Học viện Quân y
Corresponding author: Bachhvqy@gmail.com
DOI: 10.52163/yhc.v66iCD1.1962
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Keywords
Meloxicam HPLC fast dissolving films
Abstract

Objective: To validate a method for the quantification of Meloxicam in film by high performance liquid chromatography in order to contribute to product quality standardization.

Subjects and methods: Quantitative Meloxicam by high performance liquid chromatography method with GRACE Apollo C18 (4.6 × 250 mm, 5 µm), flow rate 1.0 ml/min, detector UV at 354 nm, injection volume 10 µl, mobile phase consisting of acetonitril, distilled water and glacial acetic acid (55:40:5).

Results: The method ensured suitability, specificity, linearity, repeatability, and precision as specified by ICH.

Conclusions: The quantitative method meets the requirements and can be used for the quantification of Meloxicam in film.

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