Articles Vol. 66 No. 1 07/01/2025

50. EVALUATION OF ACUTE TOXICITY OF SCORPION TURMERIC (CURCUMA RANGJUED)’S RHIZOME EXTRACTS FOR POTENTIAL MEDICINAL USE ON HUMANS

Phung Thi Kim Hue1,2,3,4, Do Thi Thao1,3,5,6, Tran Thi Quynh Ngan2,4, Nguyen Le Bao Ngoc2,4, Nguyen Thi Duong7,8, Le Dung Sy1,3, Le Nhat Minh9,10, Ho Cong7,8, Le Tri Vien1,3
1 Institute of Health Research and Educational Development in Central Highlands
2 Hung Vuong High School for the Gifted
3 Viện Nghiên cứu Sức khỏe và Phát triển Giáo dục Tây Nguyên
4 Trường Trung học phổ thông chuyên Hùng Vương
5 Institute of Biotechnology, Vietnam Academy of Science and Technology
6 Viện Công nghệ Sinh học, Viện Hàn lâm Khoa học và Công nghệ Việt Nam
7 Thao Nguyen Duong Family Heirloom Traditional Medicine Clinic
8 Phòng khám Đông y gia truyền Thảo Nguyên Đường
9 Foreign Trade University
10 Trường Đại học Ngoại thương
Corresponding author: whitelily109@gmail.com
DOI: 10.52163/yhc.v66i1.1955
33 Views
25 Downloads
Keywords
Curcuma rangjued acute toxicity mouse model oral administration
Abstract

Objective: To evaluate the acute toxicity of rhizome extracts of Curcuma rangjued on mouse model.

Methodology: The acute toxicity testing was conducted in accordance with the OECD guideline 420 and the Vietnamese Ministry of Health's guidelines for preclinical and clinical trials of traditional and herbal medicines (Decision No. 141/QĐ-K2ĐT, released on 27 October, 2015).

Results: Oral administration of Curcuma rangjued’s rhizome extracts at the dose of 5000 mg/kg did not induce acute toxicity in mice.

Conclusions: Curcuma rangjued is a promising medicinal resource, proven to be safe and non-toxic at doses up to 5000 mg/kg body weight in experimental mice. Therefore, expanding the cultivation of Curcuma rangjued to harness this valuable medicinal resource could significantly contribute to public health.

References
[1]
Phung Thi Kim Hue et al, Taxonomic identification of an additional species, Curcuma rangjued, in the Central Highlands of Vietnam and evaluation of its inhibitory activities against cancer cell lines, Vietnam Journal of Community Medicine, Vol. 65, English version, 2024, pp. 25-30. Google Scholar
[2]
Phung Thi Kim Hue et al, Effects of glycemic regulation and acetylcholinesterase inhibition of scorpion turmeric (Curcuma rangjued) in Central Highlands, Vietnam, Vietnam Journal of Community Medicine, Vol. 65, English version, 2024, pp. 41-46. Google Scholar
[3]
Bộ Y tế, Hướng dẫn thử nghiệm tiền lâm sàng và lâm sàng thuốc đông y, thuốc từ dược liệu, Quyết định số 141/QĐ-K2ĐT ngày 27 tháng 10 năm 2015. Google Scholar
[4]
Organization for Economic Cooperation and Development (OECD), OECD guidelinesfor testing of chemicals, Section 4, health effects: Test No. 425: Acute oral toxicity: Up-and-down procedure, 2008. Google Scholar
[5]
OECD guidelinesfor testing of chemicals, Section 4, health effects: Test No. 420: Acute oral toxicity, Fixed Dose Procedure, 2001. Google Scholar
[6]
Akhila J.S, Deepa S, Alwar M.C, Acute toxicity studies and determination of median lethal dose, Curr Sci, 2007, 93: 917-920. Google Scholar
[7]
TrM4re A, Sylvin OuedrM4go, Adama Kabore, Hamidou H Tamboura and I Pierre Guissou, The acute toxicity in mice and the in vitro anthelminthic effects on Haemonchus contortus of the extracts from three plants (Cassia ieberiana, Guiera senegalensis and Sapium grahamii) used in traditional medicine in Burkina Faso, Annals of Biological Research, 2014,5 (2): 41-46. Google Scholar
[8]
Panda S.K, Tiwari P, Adhikari L, Acute Oral Toxicity Study of Turmeric Based Herbal Product in Sprague Dawley Rats, International journal of health sciences, 2022, 6 (S6), 1701-1706. Google Scholar
[9]
Walum E, Acute oral toxicity, Environmental health perspectives, 1998, 106 (suppl 2): 497-503. Google Scholar