Articles Vol. 66 No. 1 07/01/2025

47. ASSESSMENT OF THE FLUCTUATION OF ANTI SARS-COV-2 IGG CONCENTRATION IN VACCINATED PEOPLE, APPLICATION IN COVID-19 PREVENTION

Dang Duc Hoan1,2, Vu Duc Minh1,2, Pham Tien Dung1,2, Nguyen Thi Thu Phuong1,2, Vuong Dinh Ha1,2, Hoang Manh Hung1,2, Nguyen Thi Nhu Hoa1,2
1 Son Tay General Hospital
2 Bệnh viện Đa khoa Sơn Tây
Corresponding author: drdang9806@gmail.com
DOI: 10.52163/yhc.v66i1.1952
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Keywords
Covid 19 anti-SAR CoV-2 IgG vaccines Son Tay General Hospital
Abstract

Objectives: Describe the clinical characteristics of vaccinated people and study the changes in anti-SARS-CoV-2 IgG levels in people vaccinated with the COVID-19 vaccine.

Research subjects and methods: Cross-sectional descriptive study divided into 3 time points: T6 (6 months after vaccination: 400 people); T12 (12 months after vaccination: 404 people); T18 (18 months after vaccination: 411 people) on people after vaccination with CoVid-19, the medical staff of hospitals in Hanoi and volunteers participating in the study.

Results: Regarding vaccine type: the 1st and 2nd doses of all 3 groups were mainly injected with Astrazeneca vaccine, and the 3rd and 4th doses of groups T6, T12, and T18 were mainly injected with Pfize vaccine. Regarding blood type, all 3 groups had the highest rate of blood type O+ at 43.8%, 46%, and 41.6%, respectively. Regarding the number of vaccinations, groups T6 and T12 have the highest rate of 4 vaccinations at 66.3% and 82.17%, respectively; group T18 has the highest rate of 3 vaccinations at 58.6%. Antibody concentration: group T6 has the highest antibody concentration with a median of 299.78 IU/ml, group T12 has a lower antibody concentration with a median of 162.33 IU/ml, and group T18 has the lowest antibody concentration with a median of 98.19 IU/ml.

Conclusion: Group T6 BMI: underweight and obese groups had significantly lower antibody concentrations; Antibody concentrations decreased over time, highest in the 6-month postvaccination group and lowest in the 18-month post-vaccination group.

References
[1]
M. W. Tenforde, W. H. Self, K. Adams và cộng sự (2021). Association Between mRNA Vaccination and COVID-19 Hospitalization and Disease Severity. Jama, 326 (20), 2043-2054. Google Scholar
[2]
A. P. S. Munro, C. E. Jones và S. N. Faust (2024). Vaccination against COVID-19 - risks and benefits in children. Eur J Pediatr, 183 (3), 1107-1112. Google Scholar
[3]
M. Chivu-Economescu, T. Vremera, S. M. Ruta và cộng sự (2022). Assessment of the Humoral Immune Response Following COVID-19 Vaccination in Healthcare Workers: A One Year Longitudinal Study. Biomedicines, 10 (7), Google Scholar
[4]
O. S. Almalki, E. Y. Santali, A. A. Alhothali và cộng sự (2023). The role of blood groups, vaccine type and gender in predicting the severity of side effects among university students receiving COVID-19 vaccines. BMC Infect Dis, 23 (1), 378. Google Scholar
[5]
E. Nicolai, F. Tomassetti, M. Pelagalli và cộng sự (2023). The Antibodies' Response to SARSCoV-2 Vaccination: 1-Year Follow Up. Biomedicines, 11 (10), Google Scholar
[6]
C. Dimeglio, P. Trémeaux, F. Herin và cộng sự (2022). Post-vaccination SARS-CoV-2 antibody kinetics and protection duration against Omicron in elderly population. J Infect, 85 (6), 702-769. Google Scholar
[7]
L. L. van den Hoogen, M. Boer, A. Postema và cộng sự (2022). Reduced Antibody Acquisition with Increasing Age following Vaccination with BNT162b2: Results from Two Longitudinal Cohort Studies in The Netherlands. Vaccines (Basel), 10 (9), Google Scholar
[8]
K. Kontopoulou, C. T. Nakas, C. Belai và cộng sự (2022). Antibody titers after a third dose of the SARS-CoV-2 BNT162b2 vaccine in immunocompromised adults in Greece: Is a fourth dose necessary? J Med Virol, 94 (10), 5056-5060. Google Scholar
[9]
S. Y. Nam, S. W. Jeon, D. K. Jung và cộng sự (2022). Body Weight is Inversely Associated with Anti-SARS-CoV-2 Antibody Levels after BNT162b2 mRNA Vaccination in Young and Middle Aged Adults. Infect Chemother, 54 (3), 504-516. Google Scholar