Articles Vol. 66 No. 1 07/01/2025

42. RESEARCH ON THE CONCENTRATION OF TRANSFERRIN, FERRITIN, SERUM IRON IN CIRRHOTIC PATIENTS AT THAI NGUYEN CENTRAL HOSPITAL

Tran Thi Thanh Mai1,2, Duong Hong Thai1,2, Nguyen Thi Ngoc Ha1,2
1 Thai Nguyen University of Medicine and Pharmacy
2 Trường đại học Y Dược - Đại học Thái Nguyên
Corresponding author: Nhatchimai798@gmail.com
DOI: 10.52163/yhc.v66i1.1946
16 Views
19 Downloads
Keywords
cirrhosis serum iron serum ferritin serum transferrin
Abstract

Objective: Describe the changes in ferritin, transferrin, and serum iron concentrations in cirrhosis patients and analyze the relationship between changes in transferrin, serum iron and ferritin with the severity of cirrhosis according to the Child - Pugh score.

Subject and methods: 80 patients with cirrhosis treated at Thai Nguyen Central Hospital
were divided into 3 groups: cirrhosis caused by virus B or/and C, cirrhosis caused by alcohol, cirrhosis combined with alcohol and virus B or/and C. Cross-sectional descriptive study.

Results: Serum ferritin concentrations in all 3 groups caused by viruses, alcohol abuse, and the group caused by alcohol and viruses were mainly at normal and high levels, with almost no ferritin at low levels (p>0.05). Serum iron concentration in Child Pugh A group was higher than Child Pugh B and C. Serum ferritin concentration increased in Child Pugh B and C groups higher than Child Pugh A. Transferrin concentration in all 3 groups decreased (p>0.05). Serum transferrin concentration in Child Pugh A group was higher than Child Pugh C, and was lowest in Child Pugh C

Conclusion: Cirrhosis patients often have decreased serum iron and transferrin and increased ferritin.

References
[1]
Ngô Quý Châu. Xơ gan. Bệnh học nội khoa 2: Nhà xuất bản Y học Hà Nội; 2023. p. 35-48. Google Scholar
[2]
Roehlen N, Crouchet E, Baumert TF. Liver Fibrosis: Mechanistic Concepts and Therapeutic Perspectives. Cells. 2020;9(4). Google Scholar
[3]
Huang DQ, Terrault NA, Tacke F, Gluud LL, Arrese M, Bugianesi E, et al. Global epidemiology of cirrhosis - aetiology, trends and predictions. Nature reviews Gastroenterology & hepatology. 2023;20(6):388-98. Google Scholar
[4]
G A Siregar, and W Maail. Serum iron parameters in liver cirrhosis. IOP Conference Series: Earth and Environmental Science. 2018;125:012217. Google Scholar
[5]
Oikonomou T, Goulis I, Soulaidopoulos S, Karasmani A, Doumtsis P, Tsioni K, et al. High serum ferritin is associated with worse outcome of patients with decompensated cirrhosis. Annals of gastroenterology. 2017;30(2):217-24. Google Scholar
[6]
Jaurigue MM, Cappell MS. Therapy for alcoholic liver disease. World journal of gastroenterology. 2014;20(9):2143-58. Google Scholar
[7]
Nguyễn Thị Ngọc Hà, Vũ Thị Thu Hằng, Bùi Thị Thu Hương, Lâm Thị Thu Hương. Nghiên cứu sự thay đổi sắt và ferritin huyết thanh ở bệnh nhân xơ gan tại bệnh viện Trung Ương Thái Nguyên. Tạp chí y học Việt Nam. 2022;2: 2. Google Scholar
[8]
Yu Y, Jiang L, Wang H, Shen Z, Cheng Q, Zhang P, et al. Hepatic transferrin plays a role in systemic iron homeostasis and liver ferroptosis. Blood. 2020;136(6):726-39. Google Scholar