Articles Vol. 66 No. 1 07/01/2025

20. CLINICAL, SUBCLINICAL CHARACTERISTICS AND ANTIBIOTIC RESISTANCE OF CO-INFECTING BACTERIA IN CHILDREN WITH RESPIRATORY SYNCYTIAL VIRUS (RSV) PNEUMONIA

Le Thi Hoa1,2, Le Thi Hong Hanh1,2, Phung Thi Bich Thuy1,2, Bui Thi Huyen3,4, Vu Thi Huyen1,2, Nguyen Thi Thu Thuy1,2
1 Vietnam National Children’s Hospital
2 Bệnh viện Nhi Trung ương
3 ANABIO R&D Ltd. Company
4 Công ty ANABIO R&D
Corresponding author: hoayhn3004@gmail.com
DOI: 10.52163/yhc.v66i1.1920
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Keywords
Pneumonia respiratory syncytial virus (RSV) co-bacterial infection antibiotic resistance children
Abstract

Objective: Describe the clinical, subclinical characteristics and antibiotic resistance of bacterial co-infection in children with pneumonia caused by Respiratory Syncytial Virus (RSV) at the Vietnam National Children's Hospital.

Subjects and Methods: A descriptive study conducted on cases of pneumonia due to RSV and bacterial co-infection at the Center for Pulmonology and Respiratory Care, Vietnam National Children's Hospital.

Results: Among the 162 children, 58.6% were male and 41.4% were female. The majority were under 12 months old (68.9%). The most common clinical symptoms were fever (74.7%) and respiratory failure (66.7%). Subclinical tests (X-ray, hematological blood tests, CRP) clearly reflected the level of infection. The prevalence for beta-lactamases producing H. influenzae was high (72,13%) and Haemophilus influenzae showed high resistance to Ampicillin, Cefuroxime, and Cefaclor (>90%). Cefotaxime exhibited a high sensitivity rate (98.2%), and the bacteria were not resistant to Ceftriaxone, Imipenem, and Ciprofloxacin.

Conclusion: Children with RSV pneumonia commonly present with typical clinical signs such as fever, respiratory failure, and lung rales. Subclinical tests indicate significant infection. H. influenzae is the most common co-infected bacteria with a high resistance rate to many antibiotics, requiring caution in choosing antibiotics for treatment.

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