Articles Vol. 65 No. CĐ 12 - Bệnh viện Thủ Đức 12/12/2024

37. THE ACUTE TOXICITY OF THE MOUTHWASH CONTAINING CHLORHEXIDINE AND CHLORINE DIOXIDE IN MICE

Tran Thi Phuong Thao1,2, Le Nguyen Lam3,4, Pham Anh Vu Thuy5,6
1 Hong Bang International University
2 Trường Đại học Quốc Tế Hồng Bàng
3 Can Tho University of Medicine and Pharmacy
4 Trường Đại Học Y Dược Cần Thơ
5 University of Health Sciences, Vietnam National University at Ho Chi Minh City
6 Trường Đại học Khoa học Sức khỏe, Đại học Quốc gia Thành phố Hồ Chí Minh
Corresponding author: pavthuy@uhsvnu.edu.vn
DOI: 10.52163/yhc.v65iCD12.1847
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Keywords
Chlorhexidine chlorine dioxide mice mouthwash single oral dose toxicity
Abstract

Objective: This study aimed to evaluate the acute of the mouthwash containing chlorhexidine and chlorine dioxide in mice. Subject and method: Healthy Swiss albino white mice were randomized into test and physiological groups (n=10). The test solution (0,1% CHX, 0,5% ClO2) was orally administered to the test groups and the distilled warter was given to the normal group. The mortality, changes in body weight, and clinical signs were monitored 14 days after treatment with the tested mouthwash. Results: Any mortalities or changes in body weight in mice were found. Within 30 minutes after being given the test material, 30% of mice displayed watery, red eyes and difficulties fully opening them but returned to normal afterward. Conclusion: The combination of ,1% CHX, 0,5% ClO2 does not cause any mortality in mice after a single dose for 14 days.

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