Articles Vol. 65 No. CĐ 12 - Bệnh viện Thủ Đức 12/12/2024

31. FLAVONOID INHIBITORS OF XANTHINE OXIDASE IN THE TREATMENT OF GOUT: AN OVERVIEW

Nguyen Thi Thu Trang1,2, Huynh Thi Anh Thu1,2, Tran Thi Thuy Nga1,2, Tran Huu Dat1,2, Tran Huu Dat1,2, Dinh Thi Thanh Binh1,2, Dang Thi My Hue1,2, Nguyen Duy Luu1,2, Tran Que Huong1,2
1 Danang University of Medical Technology and Pharmacy
2 Trường Đại học Kỹ thuật Y - Dược Đà Nẵng
Corresponding author: tqhuong@dhktyduocdn.edu.vn
DOI: 10.52163/yhc.v65iCD12.1841
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Keywords
Acid uric flavonoid xanthin oxidase
Abstract

Flavonoids are naturally occurring phenolic compounds, which are active ingredients that are abundantly supplemented from the diet. Flavonoids have attracted special attention from researchers due to their safety, efficacy, and low side effects in inhibiting xanthine oxidase (XO) in the treatment of Gout. Many flavonoids show the ability to inhibit XO similar to allopurinol. In this review, studies on inhibition of XO activity and Gout treatment of flavonoids are analyzed and evaluated from the aspects of chemical structure relationship and biological effects. The results indicated that hydrophobic interactions were important in binding flavonoids to XO. The ability to inhibit XO increases when the hydrophobic interaction affinity increases in flavone and flavanol groups. In particular, the planar with C2=C3 double bonds on the ring C and benzopyran ring of flavonoids are beneficial for competitive binding to the substrate of XO and inhibition of XO. Furthermore, the article also provides new perspectives on the limitations of current research aimed at promoting the development and in-depth application of flavonoids.

References
[1]
Qiyu He, et al. Global, regional, and national Google Scholar
[2]
prevalence of gout from 1990 to 2019: Age-period-cohort analysis with future burden prediction. Google Scholar
[3]
JMIR Public Health Surveill. 2023, 9: e45943. Google Scholar
[4]
doi:10.2196/45943 Google Scholar
[5]
Alghamdi AA, et al. An overview on the role of Google Scholar
[6]
xanthine oxidase inhibitors in gout management. Google Scholar
[7]
Archive Pharma Practice. 2021, 12(3), 94-9. Google Scholar
[8]
doi:10.51847 Google Scholar
[9]
Kexin Li, et al. Structure–activity relationships Google Scholar
[10]
and changes in the inhibition of xanthine oxidase Google Scholar
[11]
by polyphenols: A Review. Foods. 2024, 13(15), Google Scholar
[12]
doi:10.3390/foods13152365. Google Scholar
[13]
Jie Zhao, et al. Studies on the structure-activity Google Scholar
[14]
relationship and interaction mechanism of flavonoids and xanthine oxidase through enzyme Google Scholar
[15]
kinetics, spectroscopy methods and molecular simulations. Food Chemistry. 2022, 323, Google Scholar
[16]
doi:10.1016/j.foodchem.2020.126807 Google Scholar
[17]
Hui Xue. Mechanism of flavonoids inhibiting Google Scholar
[18]
xanthine oxidase and alleviating hyperuricemia Google Scholar
[19]
from structure–activity relationship and animal Google Scholar
[20]
experiments: A review. Food Frontiers. 2023, Google Scholar
[21]
(4), 1643-1665. doi:10.1002/fft2.287 Google Scholar
[22]
Zhang, et al. Mechanistic insights into the inhibition of quercetin on xanthine oxidase. International Journal of Biological Macromolecules. 2018, 112, 405-412. doi:10.1016/j. Google Scholar
[23]
ijbiomac.2018.01.190 Google Scholar
[24]
Wang Yajie, et al. Novel insights into the inhibitory mechanism of kaempferol on xanthine oxidase. Journal of Agricultural and Food Chemistry. 2015, 21;63(2), 526-34. doi:10.1021/ Google Scholar
[25]
jf505584m. Google Scholar
[26]
Lin Suyun, et al. Dietary flavonoids as xanthine Google Scholar
[27]
oxidase inhibitors: Structure–affinity and structure–activity elationships. Journal of Agricultural and Food Chemistry. 2015, 63 (35), 7784– Google Scholar
[28]
doi: 10.1021/acs.jafc.5b03386. Google Scholar
[29]
Li Jun, et al. Xanthine oxidase inhibitory activity of quercetin and its derivatives: Interaction mechanism and evaluation methods. Food Google Scholar
[30]
Bioscience. 2024, 59, 103982. doi:10.1016/j. Google Scholar
[31]
fbio.2024.103982. Google Scholar
[32]
Wu Junhao, et al. Beneficial properties and Google Scholar
[33]
mechanisms of natural phytochemicals to combat and prevent hyperuricemia and gout. Trends Google Scholar
[34]
in Food Science & Technology. 2023, 138, 355- Google Scholar
[35]
doi:10.1016/j.tifs.2023.06.021 Google Scholar