Articles Vol. 65 No. 6 30/10/2024

49. THE BENEFITS OF BREASTFEEDING ON BREAST CANCER RISK IN VIETNAM

Le Minh Nhan1,2, Ho Pham Thuc Lan1,2, Tang Kim Hong1,2
1 Pham Ngoc Thach University of Medicine
2 Trường Đại học Y khoa Phạm Ngọc Thạch
Corresponding author: nhanlm.pk@pnt.edu.vn
DOI: 10.52163/yhc.v65i6.1705
34 Views
7 Downloads
Keywords
Breastfeeding breast cancer case - control study risk factors
Abstract

Objective: This study aims to determine the association between breastfeeding and breast cancer risk in Vietnamese women.

Subjects and Methods: A case - control study involving 370 breast cancer patients, and 370 controls was conducted at Ho Chi Minh city Oncology Hospital from September 2023 to July 2024. A conditional logistic regression model was used to estimate the odds ratio (OR) and 95% confidence interval (CI) to evaluate the association between breastfeeding and breast cancer risk.

Results: Women who breastfed had a reduced risk of breast cancer compared to those who did not (OR = 0.59; 95%CI: 0.37-0.95; p = 0.03). Women who breastfed for 12 months or more had a lower risk of the disease compared to those who breastfed for less than 12 months (OR = 0.51; 95%CI: 0.33-0.79; p = 0.002). Women who breastfed two or more children had a reduced risk of breast cancer compared to those who breastfed fewer than two children (OR = 0.47; 95%CI: 0.31-0.71; p < 0.01). The average breastfeeding duration per child of more than 6 months was associated with a lower breast cancer risk compared to an average duration of less than 3 months (OR = 0.47; 95%CI: 0.29-0.75; p < 0.01).

Conclusions: These results highlight the crucial role of extended breastfeeding in the prevention of breast cancer.

References
[1]
Dong-Man Ye, Xiaoru Bai, Shu Xu et al, Association between breastfeeding, mammographic density, and breast cancer risk: a review, International Breastfeeding Journal, 2024, 19(1): 65. Google Scholar
[2]
Lambertini M, Santoro L, Del Mastro L et al, Reproductive behaviors and risk of developing breast cancer according to tumor subtype: A systematic review and meta-analysis of epidemiological studies, Cancer Treat Rev, 2016, 49 (65-76). Google Scholar
[3]
Yulong Chen, Pengli Jiang, Yongqin Geng, The role of breastfeeding in breast cancer prevention: a literature review, Frontiers in Oncology, 2023, 13. Google Scholar
[4]
Joanne Kotsopoulos, Jan Lubinski, Leonardo Salmena et al, Breastfeeding and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers. Breast Cancer Research, 2012, 14(2): R42. Google Scholar
[5]
Ho-Pham L.T, Nguyen T.V, The Vietnam Osteoporosis Study: Rationale and design, Osteoporos Sarcopenia, 2017, 3(2): 90-97. Google Scholar
[6]
Divya Khanna, Priyanka Sharma, Atul Budukh et al, Rural-urban disparity in cancer burden and care: findings from an Indian cancer registry, Google Scholar
[7]
BMC Cancer, 2024, 24(1): 308. Google Scholar
[8]
Collaborative Group on Hormonal Factors in Breast Cancer, Breast cancer and breastfeeding: collaborative reanalysis of individual data from 47 epidemiological studies in 30 countries, including 50302 women with breast cancer and 96973 women without the disease. Lancet, 2002, 360(9328): 187-95. Google Scholar
[9]
Abraham M, Lak M.A, Gurz D et al, A Narrative Review of Breastfeeding and Its Correlation With Breast Cancer: Current Understanding and Google Scholar
[10]
Outcomes, Cureus, 2023, 15(8): e44081. Google Scholar
[11]
Labbok M.H, Clark D, Goldman A.S, Breastfeeding: maintaining an irreplaceable immunological resource. Nat Rev Immunol, 2004, 4(7): 565-72. Google Scholar