Articles Vol. 65 No. CĐ10 - Bệnh viện Thống Nhất 30/10/2024

34. THE CORRELATION BETWEEN ULTRASOUND IMAGES AND CYTOLOGY OF SMALL THYROID NODULES AT THONG NHAT HOSPITAL

Tran Huynh Hanh Thao1,2, Nguyen Thi Mai Huong1,2, Ha Kieu Trang3,4, Phan Dang Anh Thu1,2,4,5
1 Thong Nhat Hospital
2 Bệnh viện Thống Nhất
3 University of Medicine and Pharmacy at Ho Chi Minh City
4 Trường Đại học Y Dược Thành phố Hồ Chí Minh
5 Universtiry of Medicine and Pharmacy at Ho Chi Minh City
Corresponding author: hanhthao121@gmail.com
DOI: 10.52163/yhc.v65iCD10.1622
30 Views
28 Downloads
Abstract

Introduction: Ultrasound of the thyroid is becoming increasingly common, aiding in the detection of small thyroid nodules. The indication for fine-needle aspiration (FNA) in small thyroid nodules remains a topic of much debate. However, early detection of malignant small thyroid nodules is crucial for appropriate management.

Methods: This cross-sectional descriptive study involved patients with thyroid nodules who underwent ultrasound and FNA at Thong Nhat Hospital in 2023. Ultrasound evaluations were categorized using the TIRADS system, while thyroid cytology was classified based on the 2023 Bethesda system.

Results: The study included 827 patients with 1173 thyroid nodules, who underwent both ultrasound and FNA at Thong Nhat Hospital. Among the nodules classified as TIRADS 4 and 5, most had cytological diagnoses in Bethesda categories I, II, and III, with 164 cases (26.2%), and only 46 cases (7.4%) fell into categories IV, V, and VI. The TIRADS classification was significantly correlated with the Bethesda cytological classification for benign small thyroid nodules.

Conclusion: There is a relationship between ultrasound images and cytology of small thyroid nodules, the most obvious association is thyroid nodules in TIRADS groups 1, 2, 3 (group with little suspicion of malignancy) with cytological aspiration results in the TIRADS group. II according to Bethesda (group with low risk of malignancy).

Recommendation: FNA should be performed for small thyroid nodules with malignant potential based on ultrasound assessment. Especially thyroid nodules larger than 5 mm in size. In addition, consider monitoring and re-doing FNA for patients when indicated to avoid missing cases of malignant thyroid nodules.

References
[1]
Bozkurt H et al (2016), “Comparison of 1869 thyroid ultrasound-guided fine-needle aspirationbiopsies between general surgeons and interventional radiologists”. Annals of Medicine and Surgery.10:92 – 102 Google Scholar
[2]
Anil, G., Hegde, A., & Chong, F. V. (2011). Thyroid nodules: risk stratification for malignancy with ultrasound and guided biopsy. Cancer Imaging, 11(1), 209. Google Scholar
[3]
Fiorentino, V., Dell’Aquila, M., Musarra, T., Martini, M., Capodimonti, S., Fadda, G., ... & Rossi, E. D. (2021). The role of cytology in the diagnosis of subcentimeter thyroid lesions. Diagnostics, 11(6), 1043. Google Scholar
[4]
Rossi, E. D., Pantanowitz, L., Raffaelli, M., & Fadda, G. (2021). Overview of the Ultrasound Classification Systems in the Field of Thyroid Cytology. Cancers 2021, 13, 3133. Risk Stratification of Thyroid Nodule, 145. Google Scholar
[5]
Koo, D. H., Song, K., Kwon, H., Bae, D. S., Kim, J. H., Min, H. S., ... & Youn, Y. K. (2016). Does tumor size influence the diagnostic accuracy of ultrasound-guided fine-needle aspiration cytology for thyroid nodules?. International Journal of Endocrinology, 2016. Google Scholar
[6]
Hossein Gharib, M. D., Enrico Papini, M. D., Garber, J. R., Duick, D. S., Harrell, R. M., Hegedüs, L., ... & Vitti, P. (2016). American Association Of Clinical Endocrinologists, American College Of Endocrinology, And Associazione Medici Endocrinologi Medical Guidelines For Clinical Practice For The Diagnosis And Management Of Thyroid Nodules-2016 Update Executive Summary Of Recommendations. Endocrine Practice, 22(5), 622. Google Scholar
[7]
Cooper, D. S., Doherty, G. M., Haugen, B. R., Kloos, R. T., Lee, S. L., Mandel, S. J., ... & Tuttle, R. M. (2006). Management guidelines for patients with thyroid nodules and differentiated thyroid cancer: The American Thyroid Association Guidelines Taskforce. Thyroid, 16(2), 109- 142. Google Scholar
[8]
Maia, F. F. R., Matos, P. S., Pavin, E. J., Vassallo, J., & Zantut-Wittmann, D. E. (2011). Value of ultrasound and cytological classification system to predict the malignancy of thyroid nodules with indeterminate cytology. Endocrine pathology, 22, 66-73. Google Scholar
[9]
Nabahati, M., Moazezi, Z., Fartookzadeh, S., Mehraeen, R., Ghaemian, N., & Sharbatdaran, M. (2019). The comparison of accuracy of ultrasonographic features versus ultrasound-guided fine-needle aspiration cytology in diagnosis of malignant thyroid nodules. Journal of Ultrasound, 22, 315-321. Google Scholar
[10]
Mendes, G. F., Garcia, M. R., Falsarella, P. M., Rahal, A., Cavalcante Junior, F. A., Nery, D. R., & Garcia, R. G. (2017). Fine needle aspiration biopsy of thyroid nodule smaller than 1.0 cm: accuracy of TIRADS classification system in more than 1000 nodules. The British journal of radiology, 91(1083), 20170642. Google Scholar
[11]
Trần Thị Như Quỳnh, Đặc Điểm Lâm Sàng, Hình Ảnh Siêu Âm Và Kết Quả Chọc Hút Tế Bào Bướu Nhân Tuyến Giáp Bằng Kim Nhỏ Dưới Hướng Dẫn Của Siêu Âm Google Scholar
[12]
Al-Sindi, K. A., Bukhari, M. H., Saba, K., Ali, W., Arshad, M., & Zaidi, N. R. (2013). Evaluation of non-palpable thyroid nodules by ultra sound guided fine needle aspiration cytology. Google Scholar
[13]
Mazzaferri, E. L. (2006). Managing small thyroid cancers. Jama, 295(18), 2179-2182. Google Scholar
[14]
Leenhardt, L., Grosclaude, P., & Chérié-Challine, L. (2004). Increased incidence of thyroid carcinoma in France: a true epidemic or thyroid nodule management effects? Report from the French Thyroid Cancer Committee. Thyroid, 14(12), 1056-1060. Google Scholar
[15]
Sharma, R., Verma, N., Kaushal, V., Sharma, D. R., & Sharma, D. (2017). Diagnostic accuracy of fine-needle aspiration cytology of thyroid gland lesions: A study of 200 cases in Himalayan belt. Journal of Cancer Research and Therapeutics, 13(3), 451-455. Google Scholar
[16]
Kwak, J. Y., Han, K. H., Yoon, J. H., Moon, H. J., Son, E. J., Park, S. H., ... & Kim, E. K. (2011). Thyroid imaging reporting and data system for US features of nodules: a step in establishing better stratification of cancer risk. Radiology, 260(3), 892-899. Google Scholar
[17]
Tessler, F. N., Middleton, W. D., & Grant, E. G. (2018). Thyroid imaging reporting and data system (TI-RADS): a user’s guide. Radiology, 287(1), 29-36. Google Scholar
[18]
Barbosa, T. L. M., Junior, C. O. M., Graf, H., Cavalvanti, T., Trippia, M. A., da Silveira Ugino, R. T., ... & de Carvalho, G. A. (2019). ACR TI-RADS and ATA US scores are helpful for the management of thyroid nodules with indeterminate cytology. BMC Endocrine Disorders, 19, 1-11. Google Scholar
[19]
Ali, S. Z., Baloch, Z. W., Cochand-Priollet, B., Schmitt, F. C., Vielh, P., & VanderLaan, P. A. (2023). WITHDRAWN: The 2023 Bethesda System for Reporting Thyroid Cytopathology. Google Scholar
[20]
Fadda, G., Rossi, E. D., Raffaelli, M., Pontecorvi, A., Sioletic, S., Morassi, F., ... & Rindi, G. (2011). Follicular thyroid neoplasms can be classified as low-and high-risk according to HBME-1 and Galectin-3 expression on liquid-based fine-needle cytology. European journal of endocrinology, 165(3), 447-453. Google Scholar
[21]
Schenke, S., Klett, R., Seifert, P., Kreissl, M. C., Görges, R., & Zimny, M. (2020). Diagnostic performance of different thyroid imaging reporting and data systems (Kwak-TIRADS, EU-TIRADS and ACR TI-RADS) for risk stratification of small thyroid nodules (≤ 10 mm). Journal of Clinical Medicine, 9(1), 236. Google Scholar
[22]
Chakraborty, A., Narkar, A., Mukhopadhyaya, R., Kane, S., D’Cruz, A., & Rajan, M. G. R. (2012). BRAF V600E mutation in papillary thyroid carcinoma: significant association with node metastases and extra thyroidal invasion. Endocrine pathology, 23, 83-93. Google Scholar