Articles Vol. 65 No. 6 30/10/2024

9. EVALUATE OF COMBINED METRONIDAZOLE PLUS IVERMECTINE EFFICACY IN THE TREATMENT FOR HUMAN DEMODICOSIS

Nguyen Ngoc Vinh1,2, Do Trung Dung3,4, Huynh Hong Quang1,2, Nguyen Thi Thanh Quyen1,2, Nguyen Duc Chinh1,2
1 Institute of Malariology, Parasitology, Entomology Quy Nhon
2 Viện Sốt rét – Ký sinh trùng – Côn trùng Quy Nhơn
3 National Institute of Malariology, Parasitology, and Entomology
4 Viện Sốt rét – Ký sinh trùng – Côn trùng Trung ương
Corresponding author: vinh.tmed.vn@gmail.com
DOI: 10.52163/yhc.v65i6.1571
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Keywords
Demodicosis combined metronidazole ivermectine efficacy
Abstract

Objective: To evaluate of combined metronidazole plus ivermectine (MTZ + IVM) efficacy in treatment of human demodicosis.

Methods: A non-randomized uncontrolled trial design for evaluate of combined MTZ + IVM regimen efficacy in treatment of human demodicosis.

Results: The efficacy of combined MTZ + IVM regimen in the treatment for 80 enrolled demodicosis patients showed that significantly reduced of itching, stinging, crawling ants, and erythema/ red skin, and skin scales at points of before and after one and two months intervention; Demodex density reduced from 8.8±4.5 to 1.5 ± 1.1 and 0.6 ± 0.2/ microscope field after 1 and 2 months, respectively. The proportion of high response, moderate response, and low response were 80.3% and 88.7%; 13.2% and 5.6%; 3.9% and 1.4% in one and two months post-treatment, respectively. Non-response or treatment failure at one and two months post-treatment were 2.6% and 4.3%. Some advert events in the first ten days since drugs taken included of itching, skin burning 2 (2.5%), fatigue 6 (7.5%), dizziness 2 (2.5%), abdomen pain 3 (3.8%), nausea 3 (3.8%). 

Conclusions:Combined MTZ + IVM regimen has high efficacy 80.3% and 88,7% at one and two months post-treatment, respectively.

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