Articles Vol. 65 No. CĐ 9 - Hội Gây mê Hồi sức 26/09/2024

8. REVIEW OF CLINICAL AND PARACLINICAL CHARACTERISTICS AND TREATMENT RESULTS OF STAPHYLOCCOCUS AUREUS INFECTIONS IN THE SURGICAL INTENSIVE CARE DEPARTMENT OF NGHE AN OBSTETRICS AND PEDIATRIC HOSPITAL FROM 1/2020 TO 8/2023

Tran Minh Long1,2, Nguyen Ngoc Hoa1,2, Ho Sy Son1,2
1 Nghe An Obstetrics and Pediatrics Hospital
2 Bệnh viện Sản Nhi Nghệ An
Corresponding author: longdr115@gmail.com
DOI: 10.52163/yhc.v65iCD9.1515
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Keywords
Staphylococcus aureus Vancomycin MIC
Abstract

Objectives: (1) Describe the clinical and paraclinical characteristics of Staphylococcus aureus infection treated at the Department of Surgical Intensive Care; (2) Comment on the treatment results of Staphylococcus aureus infection at the Department of Surgical Intensive Care, Nghe An Obstetrics and Pediatrics Hospital.

Subjects and methods: Retrospective and cross-sectional study. Convenient sampling of 46 patients from newborns to 15 years old diagnosed with S.aureus infection treated at the Department of Surgical Intensive Care, Nghe An Obstetrics and Pediatrics Hospital. Research period from 1/2020 to 8/2023.

Results: S.aureus infection is diverse, the primary infection is mostly from the skin - soft tissue with 80.6%; respiratory 19.4%. Clinical presentation upon admission is fever 91.3%; 80.6% of isolated S.aureus strains are resistant to Methicillin. Completely sensitive antibiotics: Vancomycin, Levofloxacin and Linezolid; 100% of patients have Vancomycin MIC ≤ 1. Treatment results: 93.5% of patients have good treatment results; 6.5% of patients need to be transferred to the higher level; no patients died; 80.5% of patients had indications for surgical intervention; 63% of patients had no metastatic foci.

Conclusion: S.aureus infection from skin - soft tissue with 80.6%; respiratory 19.4%; Completely sensitive antibiotics: Vancomycin, Levofloxacin and linezolid; 100% of patients had MIC Vancomycin ≤ 1. Treatment results were 93.5% of patients with good treatment results; 6.5% of patients needed to be transferred to the higher level.

References
[1]
Liu C, Bayer A, Cosgrove SE et al, Clinical Pradice Guidelines by the Infectious Diseases Society of Amterica for the Treatment of Methicilin - Resistant Staphylococcus aureus InfectiĨons in Adnhs and Children: Executive Summwry, Clin h/Pct Dis, 2011, 52(3): 285-292. Google Scholar
[2]
Idennis LS, Daniel H, Hany L, John LH, Donald HB, Banty H, Linezolid versus Vancomycin for the Treament of Methicilin-Resistam Staphylococcus aureus Infections, Clinic Dfeer Dis, 2002, 34(11): 1481-1490, doi:10.1086/340353. Google Scholar
[3]
Li J QH, Hoang KC, Linezolid vs Vancomycin in treatment of Methicilin-resistant Staphylococcus aureus infections: a meta-analysis, Med Pharwacol Sci, 2017, 21(17): 3974-3979. Google Scholar
[4]
Miles F, Review of Staphylococus aureus infections requiring admission to a paediatric intensive care unit, Arch Dis Child., 2015. Google Scholar
[5]
Đặng Phương Kiệt, Nhiễm khuẩn huyết do tụ cầu vàng ở trẻ em - Dung mạo lâm sàng và các yếu tố tiên lượng, Tạp chí Y học Việt Nam, 1997, 84(5). Google Scholar
[6]
Fredericsen MS, Changing epidemiology of pediatric Staphylococcus aureus bacteremia in Denmark from 1971 to 2000, Pediatrics Infect Google Scholar
[7]
Dis J., 2007. Google Scholar
[8]
Lê Thị Thanh Thủy, Nhiễm khuẩn huyết do tụ cầu vàng - Những biểu hiện lâm sàng, yếu tố tiên lượng và kháng kháng sinh, Luận văn thạc sỹ y học, Học viện Quân y, 1994. Google Scholar