Articles Vol. 65 No. CĐ 6 - Bệnh viện Lê Văn Thịnh 31/07/2024

15. NO RESPONSE TO HBV VACCINATION- SOME PRACTICAL ISSUES

Quach Thanh Lam1,2, Le Bao Tran1,2, Nguyen Duy Tai3,4, Huynh Giao1,2,3,4
1 Ho Chi Minh University of Medicine and Pharmacy
2 Đại học Y Dược Thành phố Hồ Chí Minh
3 Le Van Thinh Hospital
4 Bệnh viện Lê Văn Thịnh
Corresponding author: drquachlam@yahoo.com
DOI: 10.52163/yhc.v65iCD6.1370
19 Views
7 Downloads
Keywords
HBV (Hepatitis B Virus); HBsAg (Hepatitis B surface Antigen); Anti-HBs (Hepatitis B surface Antibody); Anti-HBc (Antibody against the core of Hepatitis B virus); occult HBV infection; no respond to HBV vaccination
Abstract

Objective: The study aims to investigate the causes and management of cases where certain individuals do not develop protective responses after receiving the hepatitis B vaccine (HBV), which is commonly observed in clinical settings.

Method: The study was conducted by searching data from two databases: PubMed and domestic studies on immune responses after hepatitis B vaccination.

Results: Literature review shows that the hepatitis B vaccine is safe and effective. However, the immune response decreases after the age of 40 and in individuals with immuno-compromised conditions. Additionally, individuals with occult HBV infection also have very poor responses to the HBV vaccine.

Conclusion: It is recommended in practice, besides the HBsAg test, to also perform the anti-HBc test before vaccination to identify these cases for better counseling

References
[1]
Phạm Hoàng Phiệt, Quách Thanh Lâm. Không đáp ứng miễn dịch sau tiêm vaccine viêm gan B. Tạp chí Y Học TP HCM số đặc biệt chuyên đề gan mật, 2006, 10(4), 27- 31. Google Scholar
[2]
Võ Ngọc Quốc Minh, Quách Thanh Lâm, Đại cương miễn dịch học, Giáo trình giảng dạy đại học. Nhà xuất bản Y học, 2023, Hồ Chí Minh, trang 1- 15. Google Scholar
[3]
World Health Organization, Hepatitis B vaccines: WHO position paper – July 2017, https:// www.who.int/publications/i/item/WER9227. Accessed 13 June, 2024. Google Scholar
[4]
Carlo S, Teresa P, Giovanni R, Occult hepatitis B virus infection: An update. Viruses, 2022 Jul 8, 14(7):1504. Google Scholar
[5]
Hội Y học TPHCM. Phân tích các dấu ấn huyết thanh của virus B gây viêm gan (HBV), http:// hoiyhoctphcm.org.vn/154/. Accessed 13 June, Google Scholar
[6]
Phạm Hoàng Phiệt, Trương Bá Trung, Đỗ Đại Hải, Vacxin trị liệu trong điều trị viêm gan virus B mạn tính hoạt động. Tạp chí Y Học TP HCM, 2004, 8(1): 48- 51. Google Scholar
[7]
Qian Y, Zang L, Liang X.M et al. Association of immune response to hepatitis B vaccine with HLA-DRB1*02, 07, 09 genes in the population Google Scholar
[8]
of Han nationlity in Quangdong province. Di Yi Jun Yi Da Xue Xue Bao, 2002, 22(1): 67- 69. Google Scholar
[9]
Wang C, Tang J, Song W et al, HLA and cytokine gene polymorphisms are independently associated with responses to hepatitis B vaccination. Hepatology, 2004, 39(4): 978- 980 Google Scholar
[10]
Hipgrave D.B, Nguyễn Thanh Vân, Vũ Mai Hương et al. Hepatitis B infection in rural Vietnam and the implications for a national program of infant immunisation. Am. J. Med. Hyg, 69(3): 288- 294, 2003. Google Scholar
[11]
King J.W, Taylor E.M, Crow S.D. Comparision of the immunogenicity of hepatitis B vaccine administered intra-dermally and intra-muscularly. Google Scholar
[12]
Rev, Infect. Dis.,1990, 12(6): 1035- 1043. Google Scholar