Articles Vol. 65 No. CĐ 7 - NCKH 24/07/2024

48. CLINICAL FEATURES AND IMAGING DIAGNOSIS OF CHILDREN WITH MOYAMOYA AT CENTRAL CHILDREN’S HOSPITAL

Le Ngoc Anh1,2, Cao Vu Hung1,2
1 Central Children’s Hospital
2 Bệnh viện Nhi Trung ương
Corresponding author: anhntnhi30@yahoo.com.vn
DOI: 10.52163/yhc.v65iCD7.1365
23 Views
6 Downloads
Keywords
Clinical features, imaging diagnosis, Moyamoya.
Abstract

Objective: Describe the clinical characteristics and imaging characteristics of children with Moyamoya disease at the Central Children’s Hospital in 2017-2023.

Research subjects and methods: The study describes a series of retrospective and prospective cases on 51 pediatric patients at the Central Children’s Hospital selected by convenience sampling method. Analyze and process data using STATA software.

Results: The proportion of pediatric patients with a Glasgow score of 15 points accounted for 60.8%, and clinical symptoms of focal paralysis accounted for the highest proportion, up to 82.3%. Evaluation of Rankin score at the time of admission showed that the proportion of pediatric patients with score 4 was quite high, reaching 62.7%. Among cases diagnosed with Moyamoya disease on admission, stroke accounts for the largest proportion, up to 43,1%, and 94.1% of these show stenosis or occlusion of the middle cerebral artery.

Conclusion: Moyamoya disease can present with transient neurological symptoms accompanying strokes and is often missed, leading to late diagnosis. Although Moyamoya disease is uncommon, the disease burden remains heavy due to high hospitalization rates, long hospital stays, and rising costs. Moyamoya should be considered and diagnostic evaluation should be initiated in patients, especially children, who present with acute neurological deterioration or unexplained symptoms related to cerebral ischemia local.

References
[1]
Hoshino H, Izawa Y, Suzuki N, Epidemiological features of moyamoya disease in Japan, Neurol Med Chir (Tokyo), 2012, 52 (5), 295-298. Google Scholar
[2]
Research Committee on the Pathology and Treatment of Spontaneous Occlusion of the Circle of Willis and Health Labour Sciences Research Grant for Research on Measures for Infractable Diseases, Guidelines for diagnosis and treatment of moyamoya disease (spontaneous occlusion of the circle of Willis), Neurol. Med. Chir. (Tokyo), 2012, 52 (5), 245-266. Google Scholar
[3]
Trần Minh Trí, Đánh giá hiệu quả điều trị bệnh lý Moyamoya bằng phương pháp phẫu thuật bắc cầu động mạch não trong và ngoài sọ, Accessed: Apr. 03, 2024. [Online]. Available: http://thu-vienso.quochoi.vn/handle/11742/62900. Google Scholar
[4]
Meena SS, Ramkumar TV, Sharma S et al., Moyamoya syndrome associated with severe iron deficiency anemia in a young child, Pediatr Hematol Oncol, 2012, 29 (4) , 368-371. Google Scholar
[5]
Mesiwala AH, Sviri G, Fatemi N et al., Long-term outcome of superficial temporal artery-middle cerebral artery bypass for patients with moyamoya disease in the US, Neurosurg Focus, 2008, 24 (2) , E15. Google Scholar
[6]
Scott R Michel, Smith Edward R, Moyamoya disease and moyamoya syndrome, N. Engl. J. Med., 2009, 360 (12), 1226-1237. Google Scholar
[7]
Kim JS, Moyamoya Disease: Epidemiology, Clinical Features, and Diagnosis, J Stroke, 2016, 18(1), 2-11. Google Scholar
[8]
Liu P, Han C, Li DS et al., Hemorrhagic Moyamoya Disease in Children: Clinical, Angiographic features, and Long-Term Surgical Outcome, Stroke, 2016, 47 (1), 240-243. Google Scholar
[9]
Scott RM, Smith JL, Robertson RL et al., Long-term outcome in children with moyamoya syndrome after cranial revascularization by pial synangiosis, J. Neurosurg, 2004, 100 (2 Suppl Pediatrics), 142-149. Google Scholar
[10]
Baik JS, Lee MS, Movement disorders associated with Moyamoya disease: a report of 4 new cases and a review of literatures, Mov. Disord. Off. J. Mov. Disord. Soc., 2010, 25 (10), 1482-1486. Google Scholar