Articles Vol. 65 No. 4 10/06/2024

41. EVALUATION OF COMPLEMENTARY EFFECTS OF DIEBETES TREATMENT AND CANCER CELL INHIBITION USING A FERMENTED PRODUCT DERIVED FROM CASHEW APPLE AND NONI FRUITS

Phung Thi Kim Hue1,2,3,4, Do Thi Thao1,3,5,6, Tran Van Loc1,3,7,8, Nguyen Cong Danh9,10, Tran Gia Hung9,10, Luong Minh Khang2,4, To Tu Hien2,4, Nguyen Tuan Khoi2,4, Le Tri Vien1,3
1 Institute of Health Research and Educational Development in Central Highlands
2 Hung Vuong Gifted High School
3 Viện Nghiên cứu Sức khoẻ và Phát triển Giáo dục Tây Nguyên
4 Trường THPT chuyên Hùng Vương
5 Institute of Biotechnology, Vietnam Academy of Science and Technology
6 Viện Công nghệ Sinh học, Viện Hàn lâm Khoa học và Công nghệ Việt Nam
7 Institute of Chemistry, Vietnam Academy of Science and Technology
8 Viện Hoá học, Viện Hàn lâm Khoa học và Công nghệ Việt Nam
9 A Sanh High School
10 Trường THPT A Sanh
Corresponding author: whitelily109@gmail.com
DOI: 10.52163/yhc.v65i4.1230
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Keywords
Diabetes, cancer, fermented product, NCF, cashew and noni, anacardic acid.
Abstract

Every year, approximately 5.6 million tons of cashew apples have been discarded in the local region
of Ia Grai District, Gia Lai Province. In addition to their sugar and mineral content, cashew apples
contain biochemical active compounds which confer various health benefits thanks to their
antioxidative, anti-inflammatory and anti-cancer properties. Noni fruits, unfortunately, encounter a
comparable outcome. Both fruits are currently considered waste products, resulting in large wastage.

Objective: The objective of this study is to evaluate the hypoglycemic and anti-proliferative cancer
cell effects of a fermented product (NCF) derived from cashew apples and noni fruits.

Method: In the study, blood glucose levels were measured using Sivalingam's (2013) methods and
Mosmann's (1983) method was employed to assess the anti-cancer properties,…

Results: The results demonstrated that the NCF contains a substantial amount of antioxidants, which
can directly or indirectly contribute to reducing blood glucose levels and inhibit cancer cell growth.
Moreover, NCF significantly lowered blood glucose levels in mice and enhanced catalase activity in
the mice’s liver (p<0.05). Notably, NCF exhibited significant anticancer effects against liver and
cervical cancer (p<0.05).

Conclusion: These findings underscore the importance of utilizing overlooked plant by products
(Cashew apple and Noni fruits) to develop functional beverages that can potentially contribute to
human health protection.

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