Articles Vol. 65 No. 4 10/06/2024

21. ASSOCIATION BETWEEN MIDAZOLAM AND POSTOPERATIVE COGNITIVE DYSFUNCTION IN ELDERLY PATIENTS FOLLOWING JOINT ARTHROPLASTY

Bui Duc Thanh1,2, Bui Quoc Khanh1,2
1 175 Military Hospital
2 Bệnh viện Quân Y 175
Corresponding author: buiducthanh175@yahoo.com
DOI: 10.52163/yhc.v65i4.1209
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Keywords
Postoperative cognitive dysfunction, elderly people.
Abstract

Background: Postoperative cognitive dysfunction greatly affects the quality of recovery after
surgery, especially in the elderly, prolonging hospital stay. To reduce anxiety and stress for patients
who are anesthetized with spinal anesthesia using sedation. Therefore, we hypothesized that the use
of midazolam sedation during surgery is related to postoperative cognitive dysfunction in elderly
patients following joint arthroplasty.

Objective: Determine the relationship between midazolam and cognitive disorders after joint
replacement surgery in the elderly.

Materials and Methods: Elderly patients (≥ 60 years) receiving spinal anesthesia for joint
arthroplasty. Design of this study is longitudinal observational, prospective, single-center.

Results: 22,5% of elderly patients had postoperative cognitive dysfunction for joint arthroplasty and
received spinal anesthesia in the first 5 days of surgery. Elderly patients with postoperative cognitive
dysfunction have a longer postoperative treatment (p < 0.05). Multivariable Cox regression analysis
noted that using of sedative midazolam during surgery (p=0,002) was a risk factor for postoperative
cognitive dysfunction.

Conclusions: Of all the 107 patients, we noted that elderly patients with postoperative cognitive
dysfunction have a longer postoperative treatment. The use of sedative midazolam during surgery is
a risk factor for postoperative cognitive dysfunction.

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