Articles Vol. 65 No. 4 10/06/2024

18. GENOTYPIC CHARACTERISTICS OF CHLAMYDIA TRACHOMATIS ISOLATED FROM INFERTILE WOMEN EXAMINED AND TREATED AT THE NATIONAL HOSPITAL OF OBSTETRICS AND GYNECOLOGY (2020 - 2021)

Hoang Dinh Canh1,2, Tran Hong Tram3,4, Cao Ba Loi1,2
1 National Institute of Malariology, Parasitology and Entomology
2 Viện Sốt rét - Ký sinh trùng - Côn trùng Trung ương
3 National Institute for Control of Vaccines and Biologicals
4 Viện Kiểm định Quốc gia Vắc xin và Sinh phẩm y tế
Corresponding author: hoangcanh@yahoo.com
DOI: 10.52163/yhc.v65i4.1205
18 Views
21 Downloads
Keywords
Infertility, Chlamydia trachomatis, genotypes
Abstract

Objectives: The study was conducted on infertile women who had been examined and treated at the National Hospital of Obstetrics and Gynecology to determine the genotypic characteristics of C. trachomatis isolated from them.

Methods: The study was designed using descriptive research method with laboratory experimental analysis

Results: Among 761 women examined and treated at the National Hospital of Obstetrics and Gynecology, 119 women (15.6%) were found to be infected with C. trachomatis. Results of genotyping by sequencing of 81 cervical C. trachomatis samples showed 9 different genotypes identified, including: B/Ba, D/Da, E, F, G/Ga, H, I/Ia, J, and K, of which genotype E accounted for the highest proportion of 25.93%, followed by D/Da (22.23%), F (13.58%), G/Ga (12.35%), J (12.35%), H (6.17%), K (3.70%), B/Ba (2.47%), and I/Ia (1.23%). Genotypes B/Ba, D/Da, H, I/Ia, J and K consisted of 1 to 10 nucleotides which were different from the reference sequences, including 19 changed positions, of which 7 nucleotide changes led to amino acid substitution. Genotype H in the women with a history of miscarriage was significantly higher than that in the women without a history of miscarriage. The rate of genotype F in the primary infertile women was significantly higher than that in the secondary infertile group.

Conclusions: A total of nine serotypes were identified, and serotypes H and F are the key factors of female infertility.

References
[1]
Beni BT, Motamedi H, Ardakani MR, Genotyping Google Scholar
[2]
of the prevalent Chlamydia trachomatis strains Google Scholar
[3]
involved in cervical infactions in woman in Ahvaz Google Scholar
[4]
Iran, Journal of Medical Microbiology, Vol.59(9), Google Scholar
[5]
, 1023-1028. Google Scholar
[6]
Liu L-1, Sun S, Zhang L et al., High prevalence Google Scholar
[7]
and circulant genotypes of Chlamydia Google Scholar
[8]
trachomatis ompA genotypes and its assocciatim Google Scholar
[9]
with abnormal cervical cytology among woman Google Scholar
[10]
of reproductive age in Shenzhen China, Frontiers Google Scholar
[11]
in Public Health, 2022, Vol.10:1036264 Google Scholar
[12]
Phạm Đăng Bảng, Đặng Văn Em, Đặc điểm lâm Google Scholar
[13]
sàng của các týp Chlamydia trachomatis, Tạp chí Google Scholar
[14]
Y Dược lâm sàng 108, Vol.6(4):64-70, 2011 Google Scholar
[15]
Tang Y, Yang X, Duan L et al., Genetic and Google Scholar
[16]
clinical characteristics of gennital Chlammydia Google Scholar
[17]
trachomatis infaction in Guangzhou, China, Google Scholar
[18]
Infection Genetics and Evulution, Google Scholar
[19]
Vol.101:105285, 2022. Google Scholar
[20]
Gao X, Chen XS, Yin YP et al., Chlamydia Google Scholar
[21]
trachomatis and Human Papillomavirus Infaction Google Scholar
[22]
in Women From Siuthern Human Provice in Google Scholar
[23]
China: A Large Obsrvational Study, Frontiers in Google Scholar
[24]
Microbiology, 2020, Vol.11:827 Google Scholar
[25]
Liu L-1, Sun S, Zhang L et al., High prevalence Google Scholar
[26]
and circulant genotypes of Chlamydia Google Scholar
[27]
trachomatis ompA genotypes and its assocciatim Google Scholar
[28]
with abnormal cervical cytology among woman Google Scholar
[29]
of reproductive age in Shenzhen China, Frontiers Google Scholar
[30]
in Public Health, Vol.10:1036264, 2022. Google Scholar
[31]
Casillas –Vega N, Morfin-Otero R, Garcia S, Google Scholar
[32]
Frequency and genotypes of Chlamydia Google Scholar
[33]
trachomatis in patients attending the obstetrics and Google Scholar
[34]
gynecology clinical in jalisco, Mexico and factors, Google Scholar
[35]
BMC Womens Health, Vol.17(1):83, 2017. Google Scholar