Articles Vol. 65 No. CĐ 4 - Hội Y học Giới tính Việt Nam 30/05/2024

3. IDENTIFY SPERM CHARACTERISTICS IN PATIENTS WITH FERTILITY ABNORMALITIES FROM 2023 TO 2024

Pham Tan Hung1,2, Tran Thuy Tien1,2, Nguyen Ngoc Hieu3,4, Tran Vo Truc Linh1,2, Huynh Anh Tu1,2, Nguyen Thanh Truc1,2, Nguyen Thi Han Ny5,6, Le Huu Tung7,8, Nguyen Van Huong1,2
1 Nguyen Tat Thanh University
2 Trường Đại học Nguyễn Tất Thành
3 Duy Tan University
4 Trường Đại học Duy Tân
5 Hospital for Tropical Disease
6 Bệnh viện Nhiệt Đới
7 Le Van Thinh Hospital
8 Bệnh viện Lê Văn Thịnh
Corresponding author: huongnv@ntt.edu.vn
DOI: 10.52163/yhc.v65iCD4.1152
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Keywords
Male infertility, DNA fragmentation, semen analysis, sperm, karyotype.
Abstract

 Objective: This study aims to identify the culprits and assess the risk of infertility in male patients. The characteristics of sperm, sperm DNA and chromosomes of groups of infertile patients, patients whose wives have a history of 2-3 consecutive miscarriages are compared to those with normal fertility.

Methods: Analyze influencing factors, determine the possibility of sperm DNA breakage and the impact of abnormal chromosomes on fertility in men. Analyzing relevant factors, determining the possibility of sperm DNA fragmentation and the effect of abnormal chromosomes on fertility in men.

Results: Semen volume, total sperm count, survival rate, pH, lysis time in infertile patients are lower, semen has high viscosity, low viscosity, acidic pH and normal sperm shape low, sperm mobility and movement speed were 2 - 3.3 times slower but the number of white blood cells and red blood cells was higher than other groups. Infertility appears at the age of 35-40, accounting for the highest rate of 36% (p<0.05), of which 100% of infertile patients have broken sperm DNA (p<0.05), 35% of patients whose wives had a history of 2-3 miscarriages had chromosomes of abnormal size and number, and did not appear in control group.

References
[1]
Infertility – World Health Organization (WHO) Google Scholar
[2]
Bunting L, Boivin J, Knowledge about infertility Google Scholar
[3]
risk factors, fertility myths and illusory benefits Google Scholar
[4]
of healthy habits in young people. Hum Google Scholar
[5]
Reprod. 2008;23(8):1858‐1864. 10.1093/ Google Scholar
[6]
humrep/den168. Google Scholar
[7]
Inhorn MC, Patrizio P, Infertility around the Google Scholar
[8]
globe: new thinking on gender, reproductive Google Scholar
[9]
technologies and global movements in Google Scholar
[10]
the 21st century. Hum Reprod Update. Google Scholar
[11]
;21(4):411‐426. 10.1093/humupd/dmv016. Google Scholar
[12]
World Health Organization. WHO Laboratory Google Scholar
[13]
Manual For The Examination And Processing Google Scholar
[14]
Of Human Semen. Geneva: World Health Google Scholar
[15]
Organization; 2021. Google Scholar
[16]
Ekin Ozkan; Marcelo P. Lacerda. Genetics, Google Scholar
[17]
Cytogenetic Testing And Conventional Google Scholar
[18]
Karyotype, Treasure Island (FL): StatPearls Google Scholar
[19]
Publishing, August 8, 2023. Google Scholar
[20]
Mona B, Leif B, Aleksander G, Sperm chromatin Google Scholar
[21]
structure assay (SCSA): a tool in diagnosis and Google Scholar
[22]
treatment of infertility, Asian J Androl. 2011 Google Scholar
[23]
Jan; 13(1): 69–75. Google Scholar
[24]
Nadia A du Fossé, Marie-Louise P van der Google Scholar
[25]
Hoorn , Jan M M van Lith et al., Advanced Google Scholar
[26]
paternal age is associated with an increased risk Google Scholar
[27]
of spontaneous miscarriage: a systematic review Google Scholar
[28]
and meta-analysis. Hum Reprod Update. 2020 Google Scholar
[29]
Sep; 26(5): 650–669 Google Scholar
[30]
Arnold Peter Paul Achermann, Sandro C. Esteves, Google Scholar
[31]
Diagnosis and management of infertility due to Google Scholar
[32]
ejaculatory duct obstruction: summary evidence, Google Scholar
[33]
Int Braz J Urol. 2021 Jul-Aug; 47(4): 868–881. Google Scholar
[34]
Jie L, Xiaoyan L, Jiahui Q et al., Association Google Scholar
[35]
between heavy metals exposure and infertility Google Scholar
[36]
among American women aged 20–44 years: Google Scholar
[37]
A cross-sectional analysis from 2013 to 2018 Google Scholar
[38]
NHANES data. Front Public Health. 2023; 11: Google Scholar
[39]
Kavindra KK, Ashok A, Ralf H et al., Radiations Google Scholar
[40]
and male fertility. Reprod Biol Endocrinol. 2018; Google Scholar
[41]
: 118 Google Scholar