Articles Vol. 65 No. CĐ 4 - Hội Y học Giới tính Việt Nam 30/05/2024

3. IDENTIFY SPERM CHARACTERISTICS IN PATIENTS WITH FERTILITY ABNORMALITIES FROM 2023 TO 2024

Hung Pham Tan1, Tien Tran Thuy1, Hieu Nguyen Ngoc2, Linh Tran Vo Truc1, Tu Huynh Anh1, Truc Nguyen Thanh1, Ny Nguyen Thi Han3, Tung Le Huu4, Huong Nguyen Van1
1 Nguyen Tat Thanh University
2 Duy Tan University
3 Hospital for Tropical Disease
4 Le Van Thinh Hospital
Corresponding author: huongnv@ntt.edu.vn
DOI: 10.52163/yhc.v65iCD4.1152
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Abstract

 Objective: This study aims to identify the culprits and assess the risk of infertility in male patients. The characteristics of sperm, sperm DNA and chromosomes of groups of infertile patients, patients whose wives have a history of 2-3 consecutive miscarriages are compared to those with normal fertility.

Methods: Analyze influencing factors, determine the possibility of sperm DNA breakage and the impact of abnormal chromosomes on fertility in men. Analyzing relevant factors, determining the possibility of sperm DNA fragmentation and the effect of abnormal chromosomes on fertility in men.

Results: Semen volume, total sperm count, survival rate, pH, lysis time in infertile patients are lower, semen has high viscosity, low viscosity, acidic pH and normal sperm shape low, sperm mobility and movement speed were 2 - 3.3 times slower but the number of white blood cells and red blood cells was higher than other groups. Infertility appears at the age of 35-40, accounting for the highest rate of 36% (p<0.05), of which 100% of infertile patients have broken sperm DNA (p<0.05), 35% of patients whose wives had a history of 2-3 miscarriages had chromosomes of abnormal size and number, and did not appear in control group.

Keywords
Male infertility, DNA fragmentation, semen analysis, sperm, karyotype.
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